{"id":"W3024838586","doi":"10.1038/s41380-020-0754-0","title":"Brain aging in major depressive disorder: results from the ENIGMA major depressive disorder working group","year":2020,"lang":"en","type":"article","venue":"Molecular Psychiatry","topic":"Functional Brain Connectivity Studies","field":"Neuroscience","cited_by":304,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; University of Alberta; Alberta Bone and Joint Health Institute; University of Calgary; McMaster University","funders":"FP7 People: Marie-Curie Actions; National Center for Complementary and Integrative Health; National Center for Advancing Translational Sciences; NIH Clinical Center; National Institute on Aging; European Regional Development Fund; National Institute of Mental Health; Helse Sør-Øst RHF; Instituto de Salud Carlos III; National Health and Medical Research Council; Canadian Institutes of Health Research; Children's Hospital Foundation; National Institutes of Health; Gratama Stichting; National Center for Research Resources; National Institute of General Medical Sciences; National Alliance for Research on Schizophrenia and Depression; Leids Universitair Medisch Centrum; University of Minnesota; Vetenskapsrådet; Eunice Kennedy Shriver National Institute of Child Health and Human Development; University of California, San Francisco; EU Joint Programme – Neurodegenerative Disease Research; Rivierduinen; European Commission; Fundação de Amparo à Pesquisa do Estado de São Paulo; Alberta Children's Hospital Foundation; Departament d'Innovació, Universitats i Empresa, Generalitat de Catalunya; FP7 Health; Generalitat de Catalunya; Sam and Rose Stein Institute for Research on Aging; American Foundation for Suicide Prevention; Bundesministerium für Bildung und Forschung; Irish Research Council; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Ministerio de Ciencia e Innovación; University of California, San Diego; University of New South Wales; Australian Government; Norges Forskningsråd; Stiftelsen för Strategisk Forskning; South African Medical Research Council; H. Lundbeck A/S; Health Research Board; National Research Foundation; National Institute for Health and Care Research; Medical Research Council; Siemens Healthineers; University of Cape Town; Russian Science Foundation; Science Foundation Ireland; Nova Scotia Health Research Foundation; Ministerio de Ciencia, Innovación y Universidades; National Science Foundation; UK Research and Innovation; Brain and Behavior Research Foundation; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Dalhousie University; National Institute of Biomedical Imaging and Bioengineering; University of Texas Health Science Center at Houston; Wellcome Trust; National Institute of Child Health and Human Development; Centro de Investigación Biomédica en Red de Salud Mental; ZonMw; Deutsche Forschungsgemeinschaft; Centres de Recerca de Catalunya","keywords":"Major depressive disorder; Atrophy; Internal medicine; Psychology; Brain size; Antidepressant; Medicine; Psychiatry; Cardiology; Cognition; Magnetic resonance imaging","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004327159,0.0006048647,0.0006899281,0.0007223003,0.0003694523,0.0006431447,0.0005956662,0.0004785228,0.0005360022],"category_scores_gemma":[0.007808988,0.0002485939,0.0009916031,0.0006313078,0.0001966238,0.0003086828,0.001389738,0.000306572,0.0003714901],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002621416,"about_ca_system_score_gemma":0.0002495378,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008318409,"about_ca_topic_score_gemma":0.009205181,"domain_scores_codex":[0.9986761,0.0005694121,0.0001347094,0.0003994544,0.0001461748,0.00007399353],"domain_scores_gemma":[0.9958045,0.001178028,0.0008989134,0.001150462,0.0006178466,0.0003502588],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007265409,0.00006459558,0.9883978,0.00005516602,0.00136411,0.0000655819,0.0002066055,0.000406286,0.0003636499,0.00003428441,0.002026673,0.006288704],"study_design_scores_gemma":[0.00004848805,0.0001053258,0.997349,0.00001593211,0.0004416268,0.0001276067,0.0001412592,0.0008150949,0.00009211389,0.00005548362,0.000799495,0.000008584514],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928744,0.0005339457,0.0006120334,0.0001150324,0.00001977079,0.00003762507,0.005482882,0.00002158165,0.0003028235],"genre_scores_gemma":[0.9823297,0.0002039917,0.0005419398,0.00007609133,0.00003120228,0.00006792889,0.01650013,0.00002713697,0.0002219582],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008318409,"threshold_uncertainty_score":0.02288449,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01546976625328831,"score_gpt":0.2423306825067806,"score_spread":0.2268609162534923,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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