{"id":"W3024838586","doi":"10.1038/s41380-020-0754-0","title":"Brain aging in major depressive disorder: results from the ENIGMA major depressive disorder working group","year":2020,"lang":"en","type":"article","venue":"Molecular Psychiatry","topic":"Functional Brain Connectivity Studies","field":"Neuroscience","cited_by":304,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; University of Alberta; Alberta Bone and Joint Health Institute; University of Calgary; McMaster University","funders":"FP7 People: Marie-Curie Actions; National Center for Complementary and Integrative Health; National Center for Advancing Translational Sciences; NIH Clinical Center; National Institute on Aging; European Regional Development Fund; National Institute of Mental Health; Helse Sør-Øst RHF; Instituto de Salud Carlos III; National Health and Medical Research Council; Canadian Institutes of Health Research; Children's Hospital Foundation; National Institutes of Health; Gratama Stichting; National Center for Research Resources; National Institute of General Medical Sciences; National Alliance for Research on Schizophrenia and Depression; Leids Universitair Medisch Centrum; University of Minnesota; Vetenskapsrådet; Eunice Kennedy Shriver National Institute of Child Health and Human Development; University of California, San Francisco; EU Joint Programme – Neurodegenerative Disease Research; Rivierduinen; European Commission; Fundação de Amparo à Pesquisa do Estado de São Paulo; Alberta Children's Hospital Foundation; Departament d'Innovació, Universitats i Empresa, Generalitat de Catalunya; FP7 Health; Generalitat de Catalunya; Sam and Rose Stein Institute for Research on Aging; American Foundation for Suicide Prevention; Bundesministerium für Bildung und Forschung; Irish Research Council; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Ministerio de Ciencia e Innovación; University of California, San Diego; University of New South Wales; Australian Government; Norges Forskningsråd; Stiftelsen för Strategisk Forskning; South African Medical Research Council; H. Lundbeck A/S; Health Research Board; National Research Foundation; National Institute for Health and Care Research; Medical Research Council; Siemens Healthineers; University of Cape Town; Russian Science Foundation; Science Foundation Ireland; Nova Scotia Health Research Foundation; Ministerio de Ciencia, Innovación y Universidades; National Science Foundation; UK Research and Innovation; Brain and Behavior Research Foundation; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Dalhousie University; National Institute of Biomedical Imaging and Bioengineering; University of Texas Health Science Center at Houston; Wellcome Trust; National Institute of Child Health and Human Development; Centro de Investigación Biomédica en Red de Salud Mental; ZonMw; Deutsche Forschungsgemeinschaft; Centres de Recerca de Catalunya","keywords":"Major depressive disorder; Atrophy; Internal medicine; Psychology; Brain size; Antidepressant; Medicine; Psychiatry; Cardiology; Cognition; Magnetic resonance imaging","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002457452,0.0004394977,0.0003767233,0.00009345483,0.0006505495,0.0001727041,0.0008609286,0.0001203489,0.00003164908],"category_scores_gemma":[0.008299666,0.0003716427,0.0002281231,0.0009156308,0.0002104293,0.0002047136,0.0006074132,0.0007635764,0.00006769318],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004762895,"about_ca_system_score_gemma":0.0000765366,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006176655,"about_ca_topic_score_gemma":0.002289516,"domain_scores_codex":[0.9959829,0.0006987298,0.0005282868,0.001529235,0.0006391937,0.0006216807],"domain_scores_gemma":[0.994367,0.004454074,0.0002794311,0.0007287076,0.00003247949,0.0001382859],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003312603,0.001351801,0.622161,0.0001628193,0.0005714911,0.001194744,0.01305607,0.009658788,0.2470606,0.01752896,0.06389206,0.02004902],"study_design_scores_gemma":[0.06879323,0.001248851,0.5194001,0.002138702,0.0007452303,0.00015976,0.01149311,0.01984804,0.07830912,0.08857416,0.2015925,0.007697219],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6910537,0.005194826,0.01021653,0.2892129,0.001431605,0.0009225362,0.0001669247,0.0002304715,0.001570534],"genre_scores_gemma":[0.9473887,0.00003805063,0.0007988855,0.05105384,0.0004223956,0.0001401359,0.00002794718,0.00008184888,0.0000481906],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.256335,"threshold_uncertainty_score":0.9998736,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01546976625328831,"score_gpt":0.2423306825067806,"score_spread":0.2268609162534923,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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