{"id":"W3024889382","doi":"10.1016/j.str.2020.04.012","title":"Activation of Phospholipase C β by Gβγ and Gαq Involves C-Terminal Rearrangement to Release Autoinhibition","year":2020,"lang":"en","type":"article","venue":"Structure","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Victoria","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health","keywords":"Gq alpha subunit; CTD; Phospholipase C; Chemistry; G protein-coupled receptor; C-terminus; Diacylglycerol kinase; Phospholipase; G protein; Biophysics; Stereochemistry; Biochemistry; Enzyme; Receptor; Biology; Protein kinase C; Amino acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00002700516,0.0000838023,0.0000782655,0.00001628974,0.000035399,0.00001017989,0.00003827002,0.0000715059,0.0000438784],"category_scores_gemma":[0.00004638267,0.00007995308,0.00002332387,0.00006371101,0.00002583024,0.000004289422,0.00003875886,0.00004323356,6.875497e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005591287,"about_ca_system_score_gemma":0.0000194713,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009850393,"about_ca_topic_score_gemma":0.000001675844,"domain_scores_codex":[0.9995022,0.00002018439,0.0001127023,0.0001936143,0.00009073001,0.00008054016],"domain_scores_gemma":[0.9997138,0.000001980399,0.00005691467,0.00009209331,0.00003969912,0.00009547301],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001252718,0.000005689633,0.0001232679,0.00004047093,0.000008606399,0.000001229995,0.0001265951,0.00005583654,0.9923277,0.00005459898,0.002747821,0.004382926],"study_design_scores_gemma":[0.0003385078,0.0001667682,0.0006909329,0.00002192883,0.000007907647,0.000003166087,0.00005923786,0.0001105746,0.9883664,0.0001027553,0.01003895,0.00009283414],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966854,0.0002448773,0.001889772,0.0008463786,0.00001746306,0.0001778942,0.00008352557,0.000008304685,0.00004633754],"genre_scores_gemma":[0.9976134,0.00001242091,0.001011205,0.0009592372,0.00009697504,0.000005053376,0.0002621386,0.000008684367,0.00003086325],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007291133,"threshold_uncertainty_score":0.3260392,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007798101938699062,"score_gpt":0.2246376205915396,"score_spread":0.2168395186528406,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}