{"id":"W3024913302","doi":"10.1039/d0cc02548h","title":"Grafting multi-maleimides on antisense oligonucleotide to enhance its cellular uptake and gene silencing capability","year":2020,"lang":"en","type":"article","venue":"Chemical Communications","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Government of Northwest Territories","funders":"National Key Research and Development Program of China; National Natural Science Foundation of China","keywords":"Gene silencing; Grafting; Oligonucleotide; Chemistry; Gene; Combinatorial chemistry; Cell biology; Computational biology; Biology; Biophysics; Biochemistry; Polymer; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001719479,0.0005461255,0.0002438665,0.0002120448,0.0001008894,0.0001803555,0.0002196405,0.0003126405,0.0006479155],"category_scores_gemma":[0.0001244833,0.0001528294,0.0002181193,0.0001718477,0.000199392,0.0002171536,0.000198473,0.0003438625,0.0002084339],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002304513,"about_ca_system_score_gemma":0.000188151,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000422081,"about_ca_topic_score_gemma":0.0006822674,"domain_scores_codex":[0.9998966,0.00001003396,0.00001035225,0.00003390711,0.00002694071,0.00002208533],"domain_scores_gemma":[0.9999142,0.00001590929,0.00002547672,0.000007807203,0.00001660485,0.00002006038],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001205661,0.000004420109,0.0000258886,0.00001443356,0.000001300997,0.00001309911,0.000005106589,0.0000335849,0.9994906,0.00004881851,0.000005136324,0.0003456057],"study_design_scores_gemma":[0.000002870483,0.00005385757,0.0002654013,9.467572e-7,0.000005166958,0.00003686362,0.000002412346,0.0002517415,0.9987847,0.000009641031,0.0005842057,0.000002209538],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9820587,0.0009450018,0.01446948,0.00007565903,0.00004027102,0.00008430504,0.0001372277,0.0001550137,0.002034287],"genre_scores_gemma":[0.9844284,0.0009951034,0.01112509,0.00005440538,0.00001632533,0.00007878272,0.000192749,0.00003041736,0.003078658],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006479155,"threshold_uncertainty_score":0.002167463,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04421927338522108,"score_gpt":0.3014117211338536,"score_spread":0.2571924477486325,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}