{"id":"W3024922031","doi":"10.1016/j.jcmgh.2020.05.002","title":"High Content Imaging of Barrett’s-Associated High-Grade Dysplasia Cells After siRNA Library Screening Reveals Acid-Responsive Regulators of Cellular Transitions","year":2020,"lang":"en","type":"article","venue":"Cellular and Molecular Gastroenterology and Hepatology","topic":"Esophageal Cancer Research and Treatment","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"University of British Columbia; Imperial College London; Health Research Board","keywords":"Epithelial–mesenchymal transition; Small interfering RNA; Vimentin; Biology; Cancer research; Microarray analysis techniques; GERD; Cell; Dysplasia; Barrett's esophagus; Gene silencing; Gene expression; Cell migration; Mesenchymal stem cell; Cancer; Adenocarcinoma; Pathology; Cell biology; Gene; Metastasis; RNA; Medicine; Immunology; Genetics; Disease; Immunohistochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[{"model":"gemma","categories":[],"domain":null,"study_design":"bench_or_experimental","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"high","status":"direct model label, unvalidated"},{"model":"gpt","categories":[],"domain":null,"study_design":"bench_or_experimental","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"high","status":"direct model label, unvalidated"}],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001733617,0.0002187875,0.0002288926,0.0003159709,0.0001380508,0.0002746531,0.0001538869,0.000230045,0.001011285],"category_scores_gemma":[0.0001116915,0.0001253526,0.0002368775,0.0002352843,0.0001866864,0.0001040613,0.0001335445,0.0002771425,0.000299481],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002764588,"about_ca_system_score_gemma":0.0001371086,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000782221,"about_ca_topic_score_gemma":0.00141572,"domain_scores_codex":[0.9998689,0.00001491059,0.000009394415,0.00003729344,0.00004396312,0.0000254707],"domain_scores_gemma":[0.9998851,0.00003709682,0.00002656814,0.00001273742,0.00002216323,0.00001628927],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003745679,0.000007256181,0.0001997483,0.00001650928,0.000002525506,0.000009845993,0.000007071374,0.0000270685,0.9991186,0.00001216373,0.00001243849,0.0005493113],"study_design_scores_gemma":[0.000004809867,0.0001074395,0.01188537,0.000001961877,0.00001212586,0.00006407844,0.00001920988,0.0009008011,0.9866503,0.00001295688,0.0003384371,0.000002518133],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9864749,0.0009074031,0.010334,0.00006395076,0.00001287557,0.00003301542,0.0007170103,0.0001618722,0.001294993],"genre_scores_gemma":[0.9820785,0.0008282755,0.01274833,0.00009297385,0.000004706218,0.0001105565,0.001248223,0.00004318806,0.002845395],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001011285,"threshold_uncertainty_score":0.0033831,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01206327319610626,"score_gpt":0.2239316964704598,"score_spread":0.2118684232743535,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}