{"id":"W3024969630","doi":"10.14309/ajg.0000000000002128","title":"Ursodeoxycholic Acid Treatment–Induced GLOBE Score Changes Are Associated With Liver Transplantation-Free Survival in Patients With Primary Biliary Cholangitis","year":2022,"lang":"en","type":"article","venue":"The American Journal of Gastroenterology","topic":"Liver Diseases and Immunity","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Toronto General Hospital; University Health Network","funders":"European Association for the Study of the Liver; Stichting voor Lever- en Maag-Darm Onderzoek; Gilead Sciences; Intercept Pharmaceuticals; Dr. Falk Pharma; GlaxoSmithKline; National Institute for Health and Care Research; Falk Foundation","keywords":"Medicine; Hazard ratio; Interquartile range; Confidence interval; Globe; Internal medicine; Liver transplantation; Ursodeoxycholic acid; Proportional hazards model; Gastroenterology; Cohort; Transplantation; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002130279,0.0001712208,0.0005827346,0.0001731517,0.0001158218,0.000008897265,0.0002703669,0.00001463811,0.00005414171],"category_scores_gemma":[0.00001764219,0.0001005551,0.00008441087,0.0002626352,0.0002051921,0.00008110674,0.00004819275,0.0003690142,5.883526e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003135258,"about_ca_system_score_gemma":0.00008283959,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002471349,"about_ca_topic_score_gemma":0.0003785579,"domain_scores_codex":[0.9983414,0.0005950101,0.0002271276,0.0001418371,0.0003916475,0.0003029141],"domain_scores_gemma":[0.9987888,0.00006676106,0.0006288303,0.0002793605,0.0001222696,0.000114005],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.04080188,0.001071899,0.9549842,0.000009935025,0.0004973097,0.0004224717,0.0008829818,0.00002244669,0.00007704539,3.385593e-7,0.00003600143,0.001193486],"study_design_scores_gemma":[0.01014928,0.05332862,0.9347117,0.0000787744,0.0004456308,0.0004071296,0.0007897976,0.000003503738,0.00001320789,0.000002581802,0.000009615705,0.00006016039],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979149,0.00007090432,0.00001033003,0.001469446,0.0000698217,0.0002515674,0.0001784034,0.000009880922,0.00002481631],"genre_scores_gemma":[0.9981005,0.0001359345,0.00004328014,0.001538609,0.00004940948,0.00001640622,0.00008116362,0.00002290951,0.00001185713],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05225672,"threshold_uncertainty_score":0.4100518,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01413124465000412,"score_gpt":0.2211786614303297,"score_spread":0.2070474167803255,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}