{"id":"W3025001510","doi":"10.1101/2020.05.17.095000","title":"Prophage exotoxins enhance colonization fitness in epidemic scarlet fever-causing <i>Streptococcus pyogenes</i>","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Streptococcal Infections and Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute; Western University","funders":"National Health and Medical Research Council; Medical Research Council; Canadian Institutes of Health Research; National Institutes of Health; University of Wollongong; Wellcome Trust","keywords":"Streptococcus pyogenes; Superantigen; Prophage; Microbiology; Scarlet fever; Biology; Virulence; Neutrophil extracellular traps; Streptococcus; Immunology; Bacteriophage; Immune system; Genetics; Staphylococcus aureus; Bacteria; Gene; Medicine; Inflammation; T cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000131528,0.0001726996,0.0001768077,0.0001226981,0.00007223692,0.0002351083,0.00009165188,0.0001461414,0.001214272],"category_scores_gemma":[0.0001610077,0.000066966,0.0001293959,0.00007417817,0.0001207436,0.00008325394,0.000197226,0.000323666,0.0001769493],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001334673,"about_ca_system_score_gemma":0.0001034257,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003475961,"about_ca_topic_score_gemma":0.0003148855,"domain_scores_codex":[0.9999027,0.00002205093,0.000005512775,0.0000120677,0.00001946322,0.00003828676],"domain_scores_gemma":[0.9998844,0.00002641296,0.00002835467,0.000008686501,0.000009272633,0.00004279722],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002516881,0.00008822705,0.00179978,0.00001608195,0.000004201814,0.00004337905,0.00001404145,0.00006009876,0.9962631,0.00004078642,0.00005065965,0.001368001],"study_design_scores_gemma":[0.00005160111,0.004043361,0.09695221,0.00001255093,0.00002950983,0.0007176091,0.0001721686,0.002241402,0.8939918,0.0001259032,0.001654061,0.000007971685],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993495,0.0001159429,0.0001931438,0.00002164328,0.000003670765,0.000003812823,0.00003878142,0.000008363166,0.0002650694],"genre_scores_gemma":[0.9990357,0.00006298674,0.000289259,0.00001684863,0.000002985139,0.000003348027,0.00008819191,0.000004492863,0.0004962193],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001214272,"threshold_uncertainty_score":0.004062116,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02532462092010909,"score_gpt":0.2738919582543525,"score_spread":0.2485673373342434,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}