{"id":"W3025061287","doi":"10.1158/1078-0432.ccr-19-1905","title":"Arginine Depletion Therapy with ADI-PEG20 Limits Tumor Growth in Argininosuccinate Synthase–Deficient Ovarian Cancer, Including Small-Cell Carcinoma of the Ovary, Hypercalcemic Type","year":2020,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; Centre for Advancing Health Outcomes; BC Cancer Agency; University of British Columbia","funders":"National Cancer Institute; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Terry Fox Research Institute","keywords":"Ovarian cancer; Cancer research; Biology; Cancer; Serous carcinoma; Ovarian carcinoma; Ovary; Clear cell carcinoma; Medicine; Internal medicine; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001073779,0.0001772842,0.0001469682,0.0001316801,0.0000898771,0.0001675519,0.000102568,0.0001311654,0.0004729964],"category_scores_gemma":[0.0001004042,0.00006503549,0.0001088627,0.00009694479,0.0001326711,0.0001160633,0.0001037443,0.0002217646,0.00008137626],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002336022,"about_ca_system_score_gemma":0.0001833417,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005114248,"about_ca_topic_score_gemma":0.0009267591,"domain_scores_codex":[0.9999574,0.000005476061,0.000005242325,0.000009566819,0.00001188133,0.00001034229],"domain_scores_gemma":[0.9999632,0.000005788669,0.000008808846,0.000004496545,0.000003846979,0.00001388024],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009872512,0.0001974261,0.003899175,0.00005020798,0.00001745243,0.00009591407,0.00002479852,0.0003152144,0.9845511,0.00004775201,0.0001257318,0.009687898],"study_design_scores_gemma":[0.0001925635,0.005175535,0.04496104,0.000006498385,0.00004411646,0.001271338,0.00009565295,0.005393898,0.9394199,0.00006739145,0.003365547,0.000006506782],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992963,0.0002240663,0.0001698133,0.00001488989,0.00000342769,0.00001260193,0.00003772349,0.00001134741,0.0002297337],"genre_scores_gemma":[0.9993573,0.00009952854,0.0002369912,0.00001152024,0.000001304786,0.00001023565,0.00009914032,0.000001444789,0.000182685],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005114248,"threshold_uncertainty_score":0.001694918,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1806472035196014,"score_gpt":0.4180989622117631,"score_spread":0.2374517586921617,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}