{"id":"W3025062498","doi":"10.1016/j.euo.2020.04.005","title":"Can Patients with Muscle-invasive Bladder Cancer and Fibroblast Growth Factor Receptor-3 Alterations Still Be Considered for Neoadjuvant Pembrolizumab? A Comprehensive Assessment from the Updated Results of the PURE-01 Study","year":2020,"lang":"en","type":"article","venue":"European Urology Oncology","topic":"Bladder and Urothelial Cancer Treatments","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":false,"ca_institutions":"Decipher Biosciences (Canada)","funders":"Associazione Italiana per la Ricerca sul Cancro; Merck","keywords":"Fibroblast growth factor receptor 3; Bladder cancer; Medicine; Fibroblast growth factor receptor 4; Cancer research; Oncology; Pathological; Fibroblast growth factor receptor 2; Fibroblast growth factor receptor; Cancer; Internal medicine; Biology; Receptor; Fibroblast growth factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000741803,0.0003052803,0.0006023922,0.00003606451,0.0002189547,0.00001715815,0.0002168724,0.00008527469,0.0001460821],"category_scores_gemma":[0.0001829702,0.0001707209,0.00007949324,0.0001542012,0.0004481539,0.00004292472,0.0001800661,0.0003548989,0.00000353964],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001000952,"about_ca_system_score_gemma":0.0006110321,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000618658,"about_ca_topic_score_gemma":0.001885583,"domain_scores_codex":[0.9975241,0.0008714575,0.0004901919,0.0005968894,0.0002039425,0.000313388],"domain_scores_gemma":[0.9979825,0.0006172824,0.000380261,0.0003789835,0.0004679887,0.0001729925],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.03418401,0.006486892,0.7194226,0.0001583182,0.01253874,0.0002980286,0.08951134,0.0004012875,0.01763615,0.000254167,0.1136686,0.005439844],"study_design_scores_gemma":[0.03029381,0.0129685,0.9428592,0.00001880019,0.001369067,0.00000793562,0.00125941,0.00003969758,0.0002440366,0.00002159937,0.01073659,0.0001813064],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9533364,0.0001050149,0.00002833614,0.0382119,0.0001955471,0.003174396,0.004372414,0.00003948237,0.0005364989],"genre_scores_gemma":[0.9851519,0.00003090885,0.0002148869,0.01381762,0.0001773062,0.0001236344,0.0003799891,0.00005547243,0.00004825946],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2234366,"threshold_uncertainty_score":0.6961794,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03695168064423887,"score_gpt":0.2950758822271127,"score_spread":0.2581242015828739,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}