{"id":"W3025122719","doi":"10.1016/j.stem.2020.04.010","title":"Disrupting Mitochondrial Copper Distribution Inhibits Leukemic Stem Cell Self-Renewal","year":2020,"lang":"en","type":"article","venue":"Cell stem cell","topic":"Trace Elements in Health","field":"Nursing","cited_by":55,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre; University Health Network","funders":"Canadian Institutes of Health Research; Ontario Ministry of Research, Innovation and Science; Astellas Pharma Canada; Princess Margaret Cancer Foundation; Takeda Pharmaceutical Company; AbbVie; Ontario Institute for Cancer Research; Takeda Pharmaceuticals North America; GlaxoSmithKline","keywords":"Biology; Stem cell; Cell biology; Mitochondrion; Distribution (mathematics)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002721723,0.0005616116,0.0005567374,0.00006477624,0.0004774085,0.0001717237,0.0005173451,0.0003573525,0.00009979949],"category_scores_gemma":[0.000008867348,0.0005982578,0.0002204964,0.0004770448,0.00006185882,0.0002937688,0.0002179707,0.0007724484,0.001029331],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001046564,"about_ca_system_score_gemma":0.0001849495,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008101761,"about_ca_topic_score_gemma":0.00001711113,"domain_scores_codex":[0.9956154,0.0003681115,0.001030123,0.001071706,0.0007253271,0.001189286],"domain_scores_gemma":[0.9978763,0.0002679835,0.0005422822,0.0005701386,0.000116876,0.0006263907],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001504178,0.001506999,0.01391203,0.005770219,0.00006084254,0.0001071513,0.01972698,0.001919298,0.8234195,0.00006360807,0.1181478,0.01386145],"study_design_scores_gemma":[0.00494209,0.0008466886,0.0002435001,0.0001319728,0.0001989551,0.000007704092,0.002528423,0.001852122,0.9078798,0.00001449643,0.08035687,0.0009974004],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9830706,0.001104714,0.0004864808,0.0007849228,0.004575898,0.001344753,0.0002384398,0.000734799,0.007659441],"genre_scores_gemma":[0.9951423,0.00003785056,0.0008423263,0.0006147054,0.001650842,0.00004248928,0.0002514191,0.0001422189,0.001275829],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0844603,"threshold_uncertainty_score":0.9997485,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01905507829750071,"score_gpt":0.247638433906473,"score_spread":0.2285833556089722,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}