{"id":"W3025263087","doi":"10.1021/acschembio.0c00253","title":"CRISPR-Based Screen Links an Inhibitor of Nonsense-Mediated Decay to eIF4A3 Target Engagement","year":2020,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"Nonsense-mediated decay; CRISPR; Biology; RNA splicing; Exon; Genetics; Stop codon; Intron; RNA; Cell biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002394546,0.0004850196,0.0005874335,0.0003333039,0.0002039655,0.0003284596,0.0003531803,0.0005563887,0.002374189],"category_scores_gemma":[0.0001980641,0.0001541273,0.0003995712,0.0002445672,0.0001752516,0.0001341126,0.000239329,0.0005314198,0.0005998305],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002735067,"about_ca_system_score_gemma":0.0002625773,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005841199,"about_ca_topic_score_gemma":0.0011658,"domain_scores_codex":[0.9996884,0.00002726752,0.00002734612,0.000069949,0.0001358705,0.00005123433],"domain_scores_gemma":[0.9998841,0.00003210943,0.00003449902,0.00001193385,0.00001606843,0.00002125682],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008843844,0.00005557613,0.0001215345,0.00005162717,0.00001213371,0.0001017196,0.000005352807,0.0001484072,0.9974622,0.00008419329,0.00009963676,0.001769196],"study_design_scores_gemma":[0.0000169654,0.0005052899,0.0008707325,0.000004130238,0.00002643059,0.0001969392,0.000008428586,0.0008225299,0.9949188,0.00003074651,0.002592034,0.000007025423],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9630442,0.002050957,0.0203859,0.0003230126,0.0001400061,0.0003168674,0.003654306,0.00116768,0.008917007],"genre_scores_gemma":[0.9757448,0.0012998,0.01187251,0.0001685759,0.00001154923,0.0001604169,0.002377942,0.00009583588,0.008268526],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002374189,"threshold_uncertainty_score":0.007942498,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01663877179675648,"score_gpt":0.3167857875125238,"score_spread":0.3001470157157674,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}