{"id":"W3025321130","doi":"10.3390/microorganisms8050758","title":"Antifungal and Antibiofilm Activities and the Mechanism of Action of Repeating Lysine-Tryptophan Peptides against Candida albicans","year":2020,"lang":"en","type":"article","venue":"Microorganisms","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Institute for Information and Communications Technology Promotion; Natural Sciences and Engineering Research Council of Canada; Ministry of Science and ICT, South Korea; National Research Foundation of Korea; National Research Foundation","keywords":"Candida albicans; Biofilm; Peptide; Biochemistry; Calcein; Corpus albicans; Biology; Fluorescence microscope; Antimicrobial peptides; Intracellular; Microbiology; Mechanism of action; Tryptophan; In vitro; Fluorescence; Membrane; Amino acid; Bacteria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000174852,0.000193945,0.0004821379,0.00005142546,0.0002222649,0.00002436985,0.0001239668,0.0001405309,0.00007929702],"category_scores_gemma":[0.00005924675,0.0001442777,0.00008005049,0.0001089069,0.000889822,0.0001381153,0.0001540065,0.0002087185,0.000003145787],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009527639,"about_ca_system_score_gemma":0.00004013248,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004719449,"about_ca_topic_score_gemma":0.00004381742,"domain_scores_codex":[0.9990202,0.0001370649,0.000324938,0.000266222,0.00003679844,0.0002148236],"domain_scores_gemma":[0.9993386,0.0001489246,0.0002969376,0.0001488965,0.00004360376,0.00002306006],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002900484,0.00002500544,0.0004869039,0.0001154646,0.0001507395,0.000001492097,0.00304846,0.000001142722,0.9908648,0.002615349,0.000264724,0.002135931],"study_design_scores_gemma":[0.00140871,0.0001715803,0.0007443989,0.00006520298,0.00007724465,0.00004106432,0.006098349,0.00001372926,0.9908137,0.0001530467,0.0002654477,0.0001475053],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973986,0.000820643,0.0003869047,0.0005808261,0.0001329243,0.0001965031,0.00009237074,0.00003280162,0.0003584409],"genre_scores_gemma":[0.9983761,0.0005021652,0.0003776118,0.0003028952,0.00003797632,0.000001660123,0.00002526562,0.00002204816,0.0003543033],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003049888,"threshold_uncertainty_score":0.5883474,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01227428058485027,"score_gpt":0.2101634135408408,"score_spread":0.1978891329559905,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}