{"id":"W3025321130","doi":"10.3390/microorganisms8050758","title":"Antifungal and Antibiofilm Activities and the Mechanism of Action of Repeating Lysine-Tryptophan Peptides against Candida albicans","year":2020,"lang":"en","type":"article","venue":"Microorganisms","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Institute for Information and Communications Technology Promotion; Natural Sciences and Engineering Research Council of Canada; Ministry of Science and ICT, South Korea; National Research Foundation of Korea; National Research Foundation","keywords":"Candida albicans; Biofilm; Peptide; Biochemistry; Calcein; Corpus albicans; Biology; Fluorescence microscope; Antimicrobial peptides; Intracellular; Microbiology; Mechanism of action; Tryptophan; In vitro; Fluorescence; Membrane; Amino acid; Bacteria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002070854,0.000332688,0.000135979,0.0001746437,0.00009949721,0.000199348,0.0002187637,0.0002627639,0.000341619],"category_scores_gemma":[0.0001765698,0.00009722975,0.0002568901,0.0001240744,0.0001711864,0.0002318508,0.0001330487,0.0002121999,0.00008959275],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001335674,"about_ca_system_score_gemma":0.0001300479,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002264814,"about_ca_topic_score_gemma":0.0001732698,"domain_scores_codex":[0.9999194,0.00002162159,0.000009383661,0.000009797222,0.00001664234,0.00002307735],"domain_scores_gemma":[0.9999282,0.00001784537,0.00002344801,0.000005415616,0.000009531625,0.00001549294],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001375966,0.00003034987,0.0001722715,0.00004980234,0.000003568374,0.00006409315,0.000009020321,0.0001789358,0.9971709,0.00005814016,0.000006994043,0.00211835],"study_design_scores_gemma":[0.0000223128,0.0008460543,0.003569768,0.00001163366,0.0000197845,0.000220806,0.00002248931,0.0006857943,0.9939514,0.00003693503,0.0006065122,0.000006539534],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973538,0.001708582,0.0005351169,0.00002179693,0.000004556884,0.00001285163,0.00004122371,0.000005713574,0.0003163266],"genre_scores_gemma":[0.9970493,0.001163471,0.001301936,0.00002664604,0.000005119544,0.00001893618,0.00008304924,0.000003046731,0.0003485034],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000341619,"threshold_uncertainty_score":0.001142859,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01227428058485027,"score_gpt":0.2101634135408408,"score_spread":0.1978891329559905,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}