{"id":"W3025321979","doi":"10.1016/j.nicl.2020.102272","title":"Striatal shape alteration as a staging biomarker for Parkinson’s Disease","year":2020,"lang":"en","type":"article","venue":"NeuroImage Clinical","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Robarts Clinical Trials; Western University","funders":"Natural Sciences and Engineering Research Council of Canada; Servier; Fondation pour la Recherche Médicale; UCB; Institut de Neurosciences des Systèmes; Takeda Pharmaceutical Company; Teva Pharmaceutical Industries; Michael J. Fox Foundation for Parkinson's Research","keywords":"Parkinson's disease; Putamen; Biomarker; Neuroscience; Cohort; Medicine; Psychology; Disease; Pathology; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002075568,0.0002143021,0.000374425,0.00004217986,0.00009012509,0.00006585211,0.00009997418,0.00007098228,0.0003060092],"category_scores_gemma":[0.001604983,0.0001895237,0.0003910234,0.0001176314,0.00005580204,0.0001390997,0.00006949824,0.0001778882,0.0002127869],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002431237,"about_ca_system_score_gemma":0.0002257058,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003074207,"about_ca_topic_score_gemma":3.514243e-7,"domain_scores_codex":[0.998035,0.0001103837,0.0005118296,0.0007627617,0.0002828006,0.0002972464],"domain_scores_gemma":[0.9981999,0.0002587111,0.0001233149,0.0003198641,0.00008203203,0.001016176],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.034787,0.005552807,0.5932791,0.0007136285,0.0009211133,0.004455104,0.0002419138,0.000008694865,0.008741825,0.0008795201,0.03693823,0.3134811],"study_design_scores_gemma":[0.01232841,0.001891549,0.7124981,0.00006613469,0.0007964132,0.000008105479,0.00002522771,0.04852447,0.000458435,0.000326436,0.2227713,0.0003054028],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9854497,0.0001199438,0.002826983,0.009247048,0.0004216431,0.001187253,0.0002828928,0.0001822583,0.0002822775],"genre_scores_gemma":[0.9857933,0.00007392056,0.001475248,0.01146619,0.0006206355,0.00009002543,0.0002801445,0.00005119283,0.0001493317],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3131757,"threshold_uncertainty_score":0.7728551,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1285680906633842,"score_gpt":0.3949677190787952,"score_spread":0.2663996284154111,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}