{"id":"W3025475065","doi":"10.1089/can.2020.0010","title":"Genetic Manipulation of sn-1-Diacylglycerol Lipase and CB <sub>1</sub> Cannabinoid Receptor Gain-of-Function Uncover Neuronal 2-Linoleoyl Glycerol Signaling in <i>Drosophila melanogaster</i>","year":2020,"lang":"en","type":"article","venue":"Cannabis and Cannabinoid Research","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut universitaire de cardiologie et de pneumologie de Québec","funders":"Novo Nordisk Fonden; Wellcome Trust","keywords":"Endocannabinoid system; Diacylglycerol lipase; Drosophila melanogaster; 2-Arachidonoylglycerol; Biology; Cell biology; Diacylglycerol kinase; Retrograde signaling; AM251; Neurotransmission; Signal transduction; Cannabinoid receptor; Cannabinoid; Biochemistry; Neuroscience; Monoacylglycerol lipase; Receptor; Protein kinase C; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001098006,0.0006193494,0.0002014067,0.0004905461,0.0002823421,0.0004419766,0.000407256,0.0003279652,0.001407976],"category_scores_gemma":[0.00007946397,0.0002474024,0.0003659262,0.0002185048,0.000451082,0.0001861773,0.000362298,0.0006679651,0.000688077],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009322051,"about_ca_system_score_gemma":0.0003377116,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00209655,"about_ca_topic_score_gemma":0.004711207,"domain_scores_codex":[0.9998266,0.00001281095,0.00002506223,0.0000585149,0.00004780021,0.00002931984],"domain_scores_gemma":[0.999854,0.00001824309,0.00006232567,0.00001507784,0.00001135445,0.00003898798],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000251246,0.000008549756,0.000144044,0.0000178566,0.000003168521,0.00004815784,0.00001168252,0.00002631419,0.9992824,0.00008019961,0.00002723359,0.0003251546],"study_design_scores_gemma":[0.00001271094,0.0000417657,0.004794029,0.000009588354,0.0000145612,0.0001724825,0.00004038477,0.0006513614,0.9916655,0.00002913553,0.00256194,0.000006347006],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9848472,0.0009643703,0.006631771,0.0001895211,0.00004404702,0.000131208,0.003541799,0.0002913809,0.0033587],"genre_scores_gemma":[0.9757211,0.001004538,0.01005001,0.0001573849,0.00001278362,0.0001172053,0.003280387,0.0001748845,0.009481702],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00209655,"threshold_uncertainty_score":0.006763637,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03494183524674774,"score_gpt":0.2884908710899791,"score_spread":0.2535490358432313,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}