{"id":"W3025475065","doi":"10.1089/can.2020.0010","title":"Genetic Manipulation of sn-1-Diacylglycerol Lipase and CB <sub>1</sub> Cannabinoid Receptor Gain-of-Function Uncover Neuronal 2-Linoleoyl Glycerol Signaling in <i>Drosophila melanogaster</i>","year":2020,"lang":"en","type":"article","venue":"Cannabis and Cannabinoid Research","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut universitaire de cardiologie et de pneumologie de Québec","funders":"Novo Nordisk Fonden; Wellcome Trust","keywords":"Endocannabinoid system; Diacylglycerol lipase; Drosophila melanogaster; 2-Arachidonoylglycerol; Biology; Cell biology; Diacylglycerol kinase; Retrograde signaling; AM251; Neurotransmission; Signal transduction; Cannabinoid receptor; Cannabinoid; Biochemistry; Neuroscience; Monoacylglycerol lipase; Receptor; Protein kinase C; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001538832,0.0006205899,0.001218707,0.001033046,0.0002923713,0.0001233843,0.0003655565,0.0004739055,0.000143586],"category_scores_gemma":[0.0007406229,0.0006007007,0.0002734599,0.001989606,0.001088836,0.0003129983,0.0004897069,0.001567752,0.00001562975],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002976985,"about_ca_system_score_gemma":0.001313613,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001126075,"about_ca_topic_score_gemma":0.0001928285,"domain_scores_codex":[0.9929397,0.0006606113,0.00143575,0.001418514,0.002125607,0.001419827],"domain_scores_gemma":[0.9962102,0.00006150253,0.0003455509,0.0006949631,0.001418678,0.001269117],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003630322,0.0004422979,0.03387079,0.002694963,0.0001296894,0.0001466354,0.001731942,0.0007019602,0.8845427,0.0003279535,0.04420921,0.02757153],"study_design_scores_gemma":[0.01376198,0.01082868,0.4261246,0.0009786942,0.0003411046,0.0001848831,0.002652196,0.007810944,0.4901241,0.0005473269,0.04510481,0.001540641],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.97426,0.003423522,0.00006644209,0.01949466,0.0001955622,0.002012113,0.0001588826,0.00005258762,0.0003361885],"genre_scores_gemma":[0.9962865,0.001066503,0.00007954718,0.0007632934,0.0005629003,0.0003209339,0.00009392743,0.0001421219,0.0006842851],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3944186,"threshold_uncertainty_score":0.9996445,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03494183524674774,"score_gpt":0.2884908710899791,"score_spread":0.2535490358432313,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}