{"id":"W3025539848","doi":"10.1101/848242","title":"Transplacental innate immune training via maternal microbial exposure: the XBP1-ERN1 axis in programming dendritic cell precursors","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"IL-33, ST2, and ILC Pathways","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Institut universitaire de cardiologie et de pneumologie de Québec","funders":"National Health and Medical Research Council; Medical Research Council","keywords":"Immunology; Progenitor cell; Immune system; XBP1; Biology; Inflammation; Innate immune system; Downregulation and upregulation; Stem cell; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":["research_integrity"],"category_scores_codex":[0.00113021,0.00100113,0.001107544,0.0003848955,0.0003716892,0.0002052185,0.00136329,0.00143474,0.0001158074],"category_scores_gemma":[0.00007536362,0.0009201862,0.0003803439,0.000479442,0.0004500926,0.0002108401,0.0004576018,0.002585891,0.0004963291],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003462413,"about_ca_system_score_gemma":0.000778043,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004251118,"about_ca_topic_score_gemma":0.0000557538,"domain_scores_codex":[0.9950909,0.0006740487,0.001177756,0.001340737,0.0001731744,0.001543354],"domain_scores_gemma":[0.9976702,0.0001359855,0.0005879049,0.001278575,0.0002317507,0.00009556681],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002534263,0.000301333,0.009938532,0.0007401339,0.0002742464,0.00009168923,0.0007755984,0.00005135272,0.9874158,0.00006559273,0.0000580142,0.00003429856],"study_design_scores_gemma":[0.003388937,0.0002413424,0.04866752,0.001098213,0.0002322177,0.000001464004,0.0001035546,0.00002629517,0.9276547,0.000001985552,0.01720903,0.001374731],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9848993,0.004830196,0.0004615321,0.00008096862,0.005649494,0.001810496,0.001910827,0.0003211353,0.00003602193],"genre_scores_gemma":[0.9981375,0.0003676965,0.0005586853,0.0001103913,0.0002476256,0.0002973774,0.000009716453,0.0002009758,0.00006998116],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05976107,"threshold_uncertainty_score":0.9998616,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01066903716405715,"score_gpt":0.1937129724578191,"score_spread":0.183043935293762,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}