{"id":"W3025668491","doi":"10.1016/j.neo.2020.04.002","title":"Alternative splicing of LSD1+8a in neuroendocrine prostate cancer is mediated by SRRM4","year":2020,"lang":"en","type":"article","venue":"Neoplasia","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Janssen Biotech; Canadian Institutes of Health Research; Astellas Pharma Global Development; Lucas Foundation; U.S. Department of Defense; Gilead Sciences; National Cancer Institute; National Institutes of Health; Prostate Cancer Foundation; Institute for Prostate Cancer Research; Bayer Corporation","keywords":"Prostate cancer; Prostate; RNA splicing; Alternative splicing; Cancer; Cancer research; Biology; Immunohistochemistry; Oncology; Internal medicine; Medicine; Computational biology; Bioinformatics; Gene; Genetics; Exon","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003842591,0.0001500623,0.0003343144,0.0000865394,0.00002251463,0.000008023751,0.00009145585,0.00002559425,0.0003059274],"category_scores_gemma":[0.00005934886,0.0001186492,0.00005025087,0.000430865,0.00007100357,0.00006928038,0.00005571013,0.000258993,0.00003390858],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009481649,"about_ca_system_score_gemma":0.0001689083,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001154446,"about_ca_topic_score_gemma":0.00006796701,"domain_scores_codex":[0.9987457,0.00003379039,0.0002570351,0.0003050427,0.0003317531,0.0003267167],"domain_scores_gemma":[0.9994501,0.00005952593,0.00008027992,0.0001315739,0.00008231733,0.0001962081],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004127549,0.0004108905,0.5856851,0.0008224139,0.0003319982,0.001681146,0.01117582,0.0000960927,0.3363027,0.00003851559,0.04153493,0.01779289],"study_design_scores_gemma":[0.02013826,0.002340757,0.02783615,0.0006094128,0.0001403063,0.0000519938,0.0006894885,0.01089836,0.8967381,0.000109314,0.04004749,0.0004004534],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9739183,0.001399964,0.000004408749,0.02242724,0.00007744605,0.0006205002,0.0001889649,0.00003401452,0.001329147],"genre_scores_gemma":[0.9940455,0.002856545,0.000028655,0.001625762,0.00008121932,0.00006742459,0.00007542787,0.00002886493,0.001190589],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5604354,"threshold_uncertainty_score":0.4838375,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02428665237256586,"score_gpt":0.3207135677435231,"score_spread":0.2964269153709572,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}