{"id":"W3025707068","doi":"10.1016/j.cellimm.2020.104133","title":"The LUBAC participates in lysophosphatidic acid-induced NF-κB activation","year":2020,"lang":"en","type":"article","venue":"Cellular Immunology","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network; Princess Margaret Cancer Centre","funders":"Conseil Régional des Pays de la Loire; Centre National de la Recherche Scientifique; Ligue Contre le Cancer; Fondation pour la Recherche Médicale; Fondation ARC pour la Recherche sur le Cancer; Fondation contre le Cancer; Agence Nationale de la Recherche","keywords":"Cell biology; Biology; G protein-coupled receptor; Signal transducing adaptor protein; Signal transduction; Guanine nucleotide exchange factor; Receptor; Lysophosphatidic acid; Scaffold protein; Transcription factor; TRAF2; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002134104,0.0001472173,0.0001678296,0.00002479369,0.000141794,0.00002820554,0.0002874002,0.0001796735,0.00001931802],"category_scores_gemma":[0.0003217792,0.0001191581,0.00006962968,0.0001638372,0.00007931978,0.0000060996,0.0001282962,0.0001722579,0.0000391274],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001038766,"about_ca_system_score_gemma":0.0000634662,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002900623,"about_ca_topic_score_gemma":0.000007986254,"domain_scores_codex":[0.9988651,0.0001399449,0.0002658875,0.0003043247,0.00007872379,0.0003459844],"domain_scores_gemma":[0.9994864,0.00003258455,0.00009302948,0.0002988781,0.00003608296,0.00005297],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001085168,0.0000195052,0.0006644775,0.000003955666,0.00004235151,0.000003308663,0.0002574458,0.00002494703,0.9944479,0.0004927177,0.00008698544,0.003847846],"study_design_scores_gemma":[0.0006160488,0.0001068312,0.001340477,0.000005111744,0.00001039623,0.00000148076,0.0002336424,0.0001746381,0.9718347,0.0001012561,0.02544106,0.0001343268],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9889909,0.007725593,0.0007369534,0.001882179,0.0002989353,0.0001574225,0.000001232155,0.00001850214,0.000188302],"genre_scores_gemma":[0.998422,0.000421549,0.00006199647,0.000655627,0.0002648033,0.00004155478,0.00004923432,0.00002172902,0.00006156076],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02535407,"threshold_uncertainty_score":0.4859128,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01984125026063446,"score_gpt":0.231323377954961,"score_spread":0.2114821276943266,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}