{"id":"W3025712113","doi":"10.1128/aac.00352-20","title":"A Phase 2 Randomized, Double-Blind, Placebo-Controlled Trial of MHAA4549A, a Monoclonal Antibody, plus Oseltamivir in Patients Hospitalized with Severe Influenza A Virus Infection","year":2020,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"London Health Sciences Centre","funders":"Genentech","keywords":"Oseltamivir; Medicine; Monoclonal antibody; Placebo; Virus; Virology; Hemagglutinin (influenza); Influenza A virus; Orthomyxoviridae; Antibody; Internal medicine; Immunology; Coronavirus disease 2019 (COVID-19); Pathology; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004037319,0.0004024169,0.001824814,0.000231693,0.0001071339,0.00004937896,0.0001052007,0.0001674446,0.0001034056],"category_scores_gemma":[0.0001210977,0.0002853514,0.0002965762,0.0004117069,0.0003122091,0.0001991371,0.00006962846,0.000313879,0.000007986188],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007715091,"about_ca_system_score_gemma":0.0001937348,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006804678,"about_ca_topic_score_gemma":0.00001763976,"domain_scores_codex":[0.9976193,0.0001601797,0.0008275177,0.0004854964,0.0004764168,0.0004311027],"domain_scores_gemma":[0.9989195,0.00008124079,0.0003643353,0.0002004247,0.0002491341,0.0001853191],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9710494,0.002501544,0.01940954,0.0001927672,0.001228609,0.00001972102,0.001750085,0.00003095644,0.002016257,0.000007093528,0.0006361996,0.001157844],"study_design_scores_gemma":[0.9881225,0.004267519,0.003266844,0.0001778567,0.0002334152,0.000004351413,0.00001461335,0.0004637842,0.002172775,0.000004958238,0.0009767412,0.0002946873],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895448,0.00003491168,0.00007516133,0.0007486053,0.0000719144,0.009033197,0.00003626312,0.00004525359,0.0004098554],"genre_scores_gemma":[0.9923334,0.001359988,0.0001837176,0.005555847,0.0001470923,0.0002520656,0.00005715641,0.00005261227,0.00005814043],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01707307,"threshold_uncertainty_score":0.9999599,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04123842296430878,"score_gpt":0.3542992193559638,"score_spread":0.313060796391655,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}