{"id":"W3025712113","doi":"10.1128/aac.00352-20","title":"A Phase 2 Randomized, Double-Blind, Placebo-Controlled Trial of MHAA4549A, a Monoclonal Antibody, plus Oseltamivir in Patients Hospitalized with Severe Influenza A Virus Infection","year":2020,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"London Health Sciences Centre","funders":"Genentech","keywords":"Oseltamivir; Medicine; Monoclonal antibody; Placebo; Virus; Virology; Hemagglutinin (influenza); Influenza A virus; Orthomyxoviridae; Antibody; Internal medicine; Immunology; Coronavirus disease 2019 (COVID-19); Pathology; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001307975,0.001297259,0.002158086,0.0004521505,0.0004752431,0.0007657157,0.0006878597,0.001498056,0.007094295],"category_scores_gemma":[0.00165601,0.0006639292,0.001225301,0.000403472,0.0007188332,0.0008026483,0.0003625647,0.001541732,0.0009017684],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004956885,"about_ca_system_score_gemma":0.001141099,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009000281,"about_ca_topic_score_gemma":0.002307144,"domain_scores_codex":[0.9992793,0.0003927363,0.00005749469,0.0001234757,0.00005333907,0.00009361985],"domain_scores_gemma":[0.999298,0.0001833008,0.0001736745,0.00005307463,0.00005194702,0.0002400524],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9764864,0.007301178,0.0004646808,0.0004318122,0.0005550564,0.0000300765,0.00004080418,0.0001560629,0.003077609,0.00008804083,0.0005259819,0.0108423],"study_design_scores_gemma":[0.9610464,0.0371763,0.0009785427,0.00001172121,0.0001402696,0.0000136207,0.000007802687,0.0001340593,0.0001664687,0.00004893988,0.0002696362,0.000006249196],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9778422,0.003885262,0.0009065273,0.0005500516,0.0006562692,0.01201239,0.001671798,0.000135851,0.002339585],"genre_scores_gemma":[0.9778896,0.002135254,0.00281068,0.001310417,0.0005735231,0.01165959,0.001165988,0.00002131384,0.002433569],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007094295,"threshold_uncertainty_score":0.02373278,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04123842296430878,"score_gpt":0.3542992193559638,"score_spread":0.313060796391655,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}