{"id":"W3025713031","doi":"10.1016/j.cell.2020.03.037","title":"Targeting Aquaporin-4 Subcellular Localization to Treat Central Nervous System Edema","year":2020,"lang":"en","type":"article","venue":"Cell","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":441,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"H. Lundbeck A/S; NordForsk; Ministry of Education – Kingdom of Saudi Arabi; Novo Nordisk Fonden; Lundbeckfonden; Magnus Bergvalls Stiftelse; Aston University; Vetenskapsrådet; Natural Sciences and Engineering Research Council of Canada; International Spinal Research Trust; Biotechnology and Biological Sciences Research Council; Lunds Universitet; Crafoordska Stiftelsen; Biogen","keywords":"Aquaporin 4; Trifluoperazine; Central nervous system; Edema; Biology; Spinal cord; Calmodulin; Motility; Pharmacology; Spinal cord injury; Aquaporin; Neuroscience; Cell biology; Medicine; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003943628,0.0001109696,0.00009534707,0.00001419936,0.00005946717,0.00001484197,0.00008433018,0.00009682147,0.00002025491],"category_scores_gemma":[0.000005707484,0.0001103783,0.00005666053,0.0000881935,0.000009846324,0.00000253273,0.00001768548,0.00003028348,0.00004808173],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001548102,"about_ca_system_score_gemma":0.00001990217,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001000246,"about_ca_topic_score_gemma":0.000001417747,"domain_scores_codex":[0.9992642,0.00002018916,0.0001624721,0.0002536517,0.00009503073,0.0002044179],"domain_scores_gemma":[0.9996516,0.000001387261,0.00004072048,0.0001073662,0.00004099406,0.000157939],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007319775,0.00001944999,0.001423324,0.0001797032,0.000005610692,0.00001194407,0.0003156542,0.02191755,0.9720274,0.00003621712,0.003692389,0.0002976205],"study_design_scores_gemma":[0.0003336688,0.0001534475,0.0003843403,0.00001134947,0.00002060791,0.000001675731,0.0003279333,0.007655182,0.9543647,0.000002035671,0.03656085,0.0001841665],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8130496,0.0003907644,0.1844496,0.0002178548,0.0002258148,0.0002168223,0.000008099523,0.00004633471,0.001395105],"genre_scores_gemma":[0.9977501,0.00001753546,0.0001692275,0.0002615264,0.0006741883,0.000006226709,0.00055703,0.00002223242,0.0005419026],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1847005,"threshold_uncertainty_score":0.4501098,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00771144685454641,"score_gpt":0.1885866288415289,"score_spread":0.1808751819869824,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}