{"id":"W3025713031","doi":"10.1016/j.cell.2020.03.037","title":"Targeting Aquaporin-4 Subcellular Localization to Treat Central Nervous System Edema","year":2020,"lang":"en","type":"article","venue":"Cell","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":441,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"H. Lundbeck A/S; NordForsk; Ministry of Education – Kingdom of Saudi Arabi; Novo Nordisk Fonden; Lundbeckfonden; Magnus Bergvalls Stiftelse; Aston University; Vetenskapsrådet; Natural Sciences and Engineering Research Council of Canada; International Spinal Research Trust; Biotechnology and Biological Sciences Research Council; Lunds Universitet; Crafoordska Stiftelsen; Biogen","keywords":"Aquaporin 4; Trifluoperazine; Central nervous system; Edema; Biology; Spinal cord; Calmodulin; Motility; Pharmacology; Spinal cord injury; Aquaporin; Neuroscience; Cell biology; Medicine; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009247905,0.0002257037,0.0002404688,0.0001694519,0.0001280578,0.0001348539,0.0002545058,0.0001999195,0.0006966518],"category_scores_gemma":[0.00006205387,0.00005794145,0.0001344163,0.00008431238,0.0002209518,0.0001805583,0.0001513938,0.0004982138,0.0001750739],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002828411,"about_ca_system_score_gemma":0.0002126411,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003871329,"about_ca_topic_score_gemma":0.0008369429,"domain_scores_codex":[0.9999573,0.000008003933,0.000002345845,0.000008514555,0.000009893044,0.00001392498],"domain_scores_gemma":[0.9999803,0.000002604851,0.000007462907,0.000001632984,0.000003441845,0.000004437713],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008236295,0.00007776674,0.00008099181,0.00009572035,0.000006248182,0.00005998916,0.00001159002,0.0001069834,0.9943116,0.0003145066,0.0001490332,0.004703238],"study_design_scores_gemma":[0.00007390776,0.001119926,0.002154492,0.00001231487,0.00003261173,0.0005502009,0.00003061374,0.001266965,0.9853754,0.0003286285,0.009047815,0.000007094573],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.960231,0.01172046,0.02254198,0.001131938,0.0001856147,0.0001711198,0.0001580937,0.0003230108,0.003536663],"genre_scores_gemma":[0.988884,0.004438595,0.004962683,0.0001268934,0.00002377473,0.00005784899,0.00008031904,0.00001231324,0.001413558],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006966518,"threshold_uncertainty_score":0.002330542,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00771144685454641,"score_gpt":0.1885866288415289,"score_spread":0.1808751819869824,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}