{"id":"W3025805039","doi":"10.1371/journal.ppat.1008516","title":"Strain-specific joint invasion and colonization by Lyme disease spirochetes is promoted by outer surface protein C","year":2020,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Vector-borne infectious diseases","field":"Immunology and Microbiology","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Institute of Allergy and Infectious Diseases; Division of Integrative Organismal Systems; New York State Department of Health - Wadsworth Center; American Heart Association; National Science Foundation","keywords":"Borrelia burgdorferi; Biology; Microbiology; Lyme disease; Tropism; Dermatan sulfate; Tissue tropism; Borrelia garinii; Spirochaetaceae; Virology; Heparan sulfate; Immunology; Genetics; Antibody; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001405301,0.0003693751,0.0002167963,0.0002862754,0.0001295816,0.0002660613,0.000126602,0.0002057599,0.000587632],"category_scores_gemma":[0.000158664,0.0001532852,0.0002244585,0.0001192399,0.0002323656,0.0001116893,0.0002694486,0.0004290232,0.0001254347],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001358068,"about_ca_system_score_gemma":0.0001548612,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006068667,"about_ca_topic_score_gemma":0.000618918,"domain_scores_codex":[0.9997242,0.00004036138,0.0000234219,0.00004920831,0.00007038419,0.0000922785],"domain_scores_gemma":[0.9997894,0.00002569739,0.00005579624,0.00002970387,0.00002434948,0.00007504983],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006473654,0.00001970038,0.0004215972,0.000006633479,0.000001710268,0.00003167156,0.00001036227,0.000008326065,0.9992248,0.00001632831,0.000006572593,0.0001875779],"study_design_scores_gemma":[0.00003083386,0.002056652,0.179733,0.00001425464,0.00003370418,0.001494743,0.0002371698,0.0008810117,0.8141791,0.00008015884,0.001238544,0.00002072153],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993446,0.0001196042,0.0001598031,0.0000105258,0.000004168214,0.000005528974,0.00003443959,0.000006576635,0.0003147636],"genre_scores_gemma":[0.9989153,0.0001038445,0.0003083528,0.00002023347,0.00000322347,0.000009004771,0.0001368719,0.000004001205,0.000499224],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006068667,"threshold_uncertainty_score":0.00196588,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02265817316691881,"score_gpt":0.2041210521337006,"score_spread":0.1814628789667818,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}