{"id":"W3025812418","doi":"10.1016/j.ymthe.2020.05.007","title":"Immunity to Cas9 as an Obstacle to Persistent Genome Editing","year":2020,"lang":"en","type":"letter","venue":"Molecular Therapy","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health","keywords":"CRISPR; Population; Scopus; Cas9; Biology; Genome editing; Genetics; Medicine; Gene","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001920208,0.00037791,0.000816626,0.001081033,0.0005704589,0.003119098,0.001038151,0.001260895,0.008747054],"category_scores_gemma":[0.004679703,0.0003597174,0.0006216787,0.0008180992,0.001079462,0.002309141,0.001793913,0.00308643,0.003178586],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001117878,"about_ca_system_score_gemma":0.00124982,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001113026,"about_ca_topic_score_gemma":0.001259368,"domain_scores_codex":[0.9981602,0.0003329469,0.0001410951,0.0003116231,0.0008114573,0.0002426738],"domain_scores_gemma":[0.9975273,0.001394334,0.0002811987,0.0002462164,0.0003463976,0.0002045647],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006420793,0.0001831425,0.002567415,0.005538047,0.0002096123,0.002363472,0.0008291408,0.002235227,0.5533007,0.07771423,0.04064577,0.3137712],"study_design_scores_gemma":[0.00007709999,0.0006582362,0.002940962,0.001048224,0.0002060645,0.004922687,0.0005257956,0.00633874,0.4078734,0.02708353,0.5481932,0.0001320682],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.2625955,0.1874338,0.298808,0.04312288,0.005411413,0.0007125229,0.003397334,0.009640783,0.1888778],"genre_scores_gemma":[0.8043321,0.06954134,0.06455724,0.007569295,0.0006153494,0.000356643,0.003491379,0.00103846,0.04849818],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.008747054,"threshold_uncertainty_score":0.02926177,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01359859159609755,"score_gpt":0.286052573324436,"score_spread":0.2724539817283384,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}