{"id":"W3025812418","doi":"10.1016/j.ymthe.2020.05.007","title":"Immunity to Cas9 as an Obstacle to Persistent Genome Editing","year":2020,"lang":"en","type":"letter","venue":"Molecular Therapy","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health","keywords":"CRISPR; Population; Scopus; Cas9; Biology; Genome editing; Genetics; Medicine; Gene","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00009834176,0.0004379665,0.000316001,0.00009264779,0.0001080019,0.0000885905,0.0006283736,0.0004153509,0.00006771462],"category_scores_gemma":[0.00004931694,0.0004804809,0.000316413,0.0001574697,0.00002306325,0.000002244742,0.0002049313,0.0005641982,0.0001321854],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004124693,"about_ca_system_score_gemma":0.0000672172,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007375715,"about_ca_topic_score_gemma":0.000005893054,"domain_scores_codex":[0.9980599,0.0001064587,0.0002519257,0.0007457255,0.0003075707,0.0005283779],"domain_scores_gemma":[0.9986417,0.000006206091,0.00005275206,0.0009115462,0.0001003082,0.000287453],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004721694,0.00002401047,0.00000480641,0.00002715485,0.0002064455,0.0003074435,0.0004397925,0.001323859,0.9396687,0.00000151421,0.0555382,0.002410899],"study_design_scores_gemma":[0.000238817,0.001053259,0.00003087356,0.00001419658,0.0000214066,0.00003846363,0.00009050882,0.00001615797,0.1986716,0.00001036222,0.7993153,0.0004990512],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"commentary","genre_scores_codex":[0.6762192,0.004736504,0.02248037,0.2926882,0.0009614931,0.001503424,0.0001633308,0.0001259514,0.001121486],"genre_scores_gemma":[0.1508455,0.0001256718,0.002237844,0.8399173,0.004231995,0.0001213378,0.001416256,0.0002318893,0.0008722306],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.7437771,"threshold_uncertainty_score":0.9997647,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01359859159609755,"score_gpt":0.286052573324436,"score_spread":0.2724539817283384,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}