{"id":"W3025922770","doi":"10.1016/j.actbio.2020.05.005","title":"Early changes in cartilage pericellular matrix micromechanobiology portend the onset of post-traumatic osteoarthritis","year":2020,"lang":"en","type":"article","venue":"Acta Biomaterialia","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":111,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","keywords":"Chondrocyte; Cartilage; Osteoarthritis; Extracellular matrix; Matrix (chemical analysis); Cell biology; Materials science; Medicine; Pathology; Biology; Anatomy; Composite material","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003405386,0.0004102171,0.0004293155,0.001019,0.0002737601,0.0008865555,0.0002462284,0.0007312584,0.004217646],"category_scores_gemma":[0.0008195794,0.0003040475,0.0003340409,0.0004123661,0.000552766,0.0005779923,0.0004747685,0.000668101,0.0007989545],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002223958,"about_ca_system_score_gemma":0.0003413039,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000619932,"about_ca_topic_score_gemma":0.0008296406,"domain_scores_codex":[0.9997659,0.00002754282,0.00002147431,0.00003337929,0.00009074003,0.00006105148],"domain_scores_gemma":[0.999303,0.00007147439,0.0003425759,0.00004541629,0.0001187589,0.0001187129],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002641064,0.0003313953,0.05373165,0.000635027,0.000073979,0.005164592,0.000424275,0.0002038722,0.9079308,0.0009948808,0.0005110576,0.02735744],"study_design_scores_gemma":[0.00003411038,0.002484181,0.8318653,0.0001396704,0.00008923444,0.009176677,0.001496564,0.00062697,0.1490616,0.0009658841,0.00400859,0.00005130978],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9867079,0.006237452,0.003516113,0.0001806779,0.0001392742,0.0000881535,0.0005043663,0.00009170449,0.002534261],"genre_scores_gemma":[0.9956338,0.00166983,0.0008910795,0.00005298896,0.00005866126,0.00003138702,0.000221863,0.000007810455,0.001432527],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004217646,"threshold_uncertainty_score":0.01410943,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01621125348817084,"score_gpt":0.245644815176849,"score_spread":0.2294335616886782,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}