{"id":"W3025985782","doi":"10.3390/cells9051196","title":"Therapeutic Potential of Peroxisome Proliferator-Activated Receptor (PPAR) Agonists in Substance Use Disorders: A Synthesis of Preclinical and Human Evidence","year":2020,"lang":"en","type":"review","venue":"Cells","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; University of Toronto; Centre for Addiction and Mental Health; University of New Brunswick","funders":"","keywords":"Peroxisome proliferator-activated receptor; Nicotine; PPAR agonist; Pharmacology; Animal studies; Pioglitazone; Agonist; Receptor; Rosiglitazone; Craving; Medicine; Dopamine; Addiction; Internal medicine; Endocrinology; Psychiatry; Type 2 diabetes; Diabetes mellitus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003553256,0.0006421744,0.002033122,0.000167943,0.00005618088,0.00004370446,0.000564985,0.0008861202,0.00004060767],"category_scores_gemma":[0.0004120744,0.0005746621,0.0004528214,0.0004381394,0.0004227985,0.00002938769,0.0001996467,0.0005267569,0.000006508912],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006173185,"about_ca_system_score_gemma":0.0003917012,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002819626,"about_ca_topic_score_gemma":0.00002204867,"domain_scores_codex":[0.9961926,0.0007584886,0.001310177,0.001032463,0.0002953482,0.0004109746],"domain_scores_gemma":[0.9978251,0.0002923156,0.0009034557,0.0006766425,0.0001218764,0.0001806468],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003029326,0.0004363784,0.0007838787,0.008963071,0.0005432011,0.000004765979,0.00008138696,0.000003351462,0.8884886,0.000009682583,0.0001033401,0.1002794],"study_design_scores_gemma":[0.0005135839,0.000706479,0.00007096273,0.01061221,0.0004543301,0.000009183342,0.0000319268,0.000003706143,0.7941626,0.00001195707,0.192533,0.0008901454],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.1562198,0.8421804,0.00002098988,0.00002276368,0.0001713163,0.001205814,0.0001493086,0.0000179993,0.00001159693],"genre_scores_gemma":[0.2090998,0.7902422,0.0001720805,0.00001647854,0.0001092949,0.000159458,0.00006821181,0.00009606434,0.00003638156],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.1924296,"threshold_uncertainty_score":0.9996705,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05150606605664174,"score_gpt":0.3255432632629666,"score_spread":0.2740371972063248,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}