{"id":"W3025989931","doi":"10.3390/jcm9051443","title":"Can Circulating Cardiac Biomarkers Be Helpful in the Assessment of LMNA Mutation Carriers?","year":2020,"lang":"en","type":"article","venue":"Journal of Clinical Medicine","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Narodowe Centrum Badań i Rozwoju; Komitet Badań Naukowych; Narodowym Centrum Nauki","keywords":"Medicine; LMNA; Internal medicine; Cardiology; Heart failure; Missense mutation; Biomarker; Natriuretic peptide; Cohort; Brain natriuretic peptide; Lamin; Mutation; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001394065,0.0008461274,0.0008436763,0.001499365,0.0002262483,0.0008948104,0.0005330564,0.00152152,0.001226518],"category_scores_gemma":[0.00709323,0.0002443786,0.0003451204,0.0008019231,0.0005092688,0.0009990785,0.0003074601,0.0007954362,0.0005832196],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001505839,"about_ca_system_score_gemma":0.0002208819,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005969233,"about_ca_topic_score_gemma":0.0006995995,"domain_scores_codex":[0.9994782,0.0002100374,0.00006933912,0.00008410109,0.00009103432,0.00006738053],"domain_scores_gemma":[0.9971956,0.001114424,0.0007997105,0.0001290742,0.0003063694,0.0004549169],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004053713,0.00004806988,0.9829496,0.00004068813,0.00003389572,0.0009638465,0.00006815682,0.0001059921,0.002047452,0.00004603671,0.0002835083,0.01300737],"study_design_scores_gemma":[0.00005571322,0.001004494,0.9835878,0.0001841619,0.0001644777,0.007848511,0.0004779479,0.002512806,0.002247732,0.0005643635,0.001315203,0.000036855],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907408,0.005875407,0.0009961837,0.001021571,0.0001092704,0.00001940027,0.0002014758,0.00004317276,0.0009926378],"genre_scores_gemma":[0.9967624,0.001128608,0.001208347,0.0003138796,0.0002144574,0.00001630337,0.0001414133,0.000006509488,0.0002080325],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00152152,"threshold_uncertainty_score":0.007372618,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0485788382894595,"score_gpt":0.3935421847372053,"score_spread":0.3449633464477457,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}