{"id":"W3026026716","doi":"10.1016/j.molmet.2020.101015","title":"The type 2 diabetes gene product STARD10 is a phosphoinositide-binding protein that controls insulin secretory granule biogenesis","year":2020,"lang":"en","type":"article","venue":"Molecular Metabolism","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"H2020 European Research Council; Institute of Genetics; Institute of Molecular and Cell Biology; Wellcome Trust; Cancer Research UK; Biotechnology and Biological Sciences Research Council; Medical Research Council; National Institutes of Health; Servier; European Research Council; The Wellcome Trust DBT India Alliance; Bundesministerium für Bildung und Frauen; Agency for Science, Technology and Research; European Commission; Innovative Medicines Initiative; National Institute of Diabetes and Digestive and Kidney Diseases; Wellcome; Royal Society; Imperial College London; Diabetes UK; Technische Universität Dresden; Bundesministerium für Bildung und Forschung; Diamond Light Source; National Institute for Health and Care Research; National University of Singapore; Horizon 2020; European Federation of Pharmaceutical Industries and Associations; Horizon 2020 Framework Programme; Academy of Medical Sciences","keywords":"Biology; Proinsulin; Cell biology; Insulin; Phosphatidylinositol; Internal medicine; Phosphorylation; Endocrinology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007991026,0.0006947109,0.0002029014,0.0002114438,0.0001664098,0.0002692354,0.0002285008,0.0002277832,0.001560842],"category_scores_gemma":[0.00009904018,0.0001550031,0.0002983709,0.0002129036,0.0002728204,0.0001047168,0.0002086705,0.0003559417,0.0007931556],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003137104,"about_ca_system_score_gemma":0.0001919972,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00053791,"about_ca_topic_score_gemma":0.0006421816,"domain_scores_codex":[0.9999179,0.000007308842,0.000007352606,0.00002714891,0.000029385,0.00001086982],"domain_scores_gemma":[0.9999034,0.00001015782,0.00004210048,0.000006284322,0.000009499755,0.00002852465],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001845899,0.00002048438,0.002344318,0.00007296456,0.00001073323,0.0003175118,0.00001425085,0.00009907191,0.9940601,0.00008537909,0.0001744318,0.002616066],"study_design_scores_gemma":[0.00006918071,0.0002929319,0.06769698,0.00003586495,0.00006860635,0.003755394,0.00009348393,0.002660047,0.909825,0.0001663671,0.01531812,0.00001803322],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9855181,0.002091936,0.008307929,0.0001723496,0.0001143805,0.00002494702,0.001830676,0.0003164074,0.001623148],"genre_scores_gemma":[0.9842483,0.001900447,0.007203276,0.00008027915,0.00002734869,0.00003601018,0.003004045,0.00007800581,0.003422233],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001560842,"threshold_uncertainty_score":0.005221546,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01569398250379045,"score_gpt":0.2232243442141075,"score_spread":0.2075303617103171,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}