{"id":"W3026039042","doi":"10.1016/j.annonc.2020.03.039","title":"99P Association of gut microbiome diversity and composition with pathological complete response (pCR) after neoadjuvant chemotherapy in triple negative breast cancer","year":2020,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Foundation Medicine; Genentech; Servier; Oncolytics Biotech; Eisai; Daiichi Sankyo Europe; Bayer HealthCare; Puma Biotechnology; Clovis Oncology; Merck KGaA; Baxalta; Genomic Health; Incyte; F. Hoffmann-La Roche; Ariad Pharmaceuticals; Amgen; Pfizer; Celgene; Bristol-Myers Squibb; Eli Lilly and Company; AstraZeneca; Queen Mary University of London","keywords":"Breast cancer; Microbiome; Medicine; Internal medicine; Triple-negative breast cancer; Oncology; Chemotherapy; Firmicutes; Neoadjuvant therapy; Cancer; Gastroenterology; Biology; Bioinformatics; Genetics; 16S ribosomal RNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003398031,0.0001491833,0.0002089176,0.0003744458,0.0003096891,0.0004600182,0.0001902317,0.0004152724,0.003867498],"category_scores_gemma":[0.001923391,0.000111744,0.0003441286,0.0006720902,0.0002069376,0.0002592136,0.0004615777,0.0005754755,0.0004427774],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000159319,"about_ca_system_score_gemma":0.0001835721,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001072045,"about_ca_topic_score_gemma":0.001087944,"domain_scores_codex":[0.9997199,0.00008471445,0.00002213156,0.00005159645,0.00004827482,0.00007329034],"domain_scores_gemma":[0.999161,0.0003007199,0.000283349,0.00005943585,0.00006467625,0.0001308268],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001813496,0.00009560628,0.9786728,0.00003065591,0.0002220529,0.0002991721,0.00008045667,0.0001314687,0.00500007,0.00006380952,0.0004172535,0.01317312],"study_design_scores_gemma":[0.000007004997,0.0001594201,0.9982432,0.000006383599,0.0000479647,0.0003252371,0.0001012796,0.000333886,0.0002883723,0.00009822785,0.0003850229,0.000004114744],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980116,0.0002835218,0.0001774307,0.0001586912,0.00002196102,0.000003099588,0.0004308651,0.00000617812,0.0009065553],"genre_scores_gemma":[0.9991141,0.00007109687,0.00009677854,0.00004853876,0.00001349379,0.000005170476,0.0001998004,0.000004369401,0.0004466164],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003867498,"threshold_uncertainty_score":0.01293808,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03523865877396137,"score_gpt":0.311277339791757,"score_spread":0.2760386810177957,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}