{"id":"W3026086046","doi":"10.2147/dddt.s242514","title":"<p>A Triple Combination of Metformin, Acetylsalicylic Acid, and Oseltamivir Phosphate Impacts Tumour Spheroid Viability and Upends Chemoresistance in Triple-Negative Breast Cancer</p>","year":2020,"lang":"en","type":"article","venue":"Drug Design Development and Therapy","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; University of British Columbia; Queen's University","funders":"Natural Sciences and Engineering Research Council of Canada; Queen's University; Russian Foundation for Basic Research","keywords":"Triple-negative breast cancer; Cancer research; Viability assay; Breast cancer; Apoptosis; Cancer; Medicine; Biology; Chemistry; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005774595,0.0002966317,0.0004443718,0.00005062584,0.00009160276,0.00003960853,0.0001345444,0.0001153417,0.00003168434],"category_scores_gemma":[0.00005103643,0.0002647261,0.00004062376,0.000227382,0.0001441074,0.00003554745,0.0000586405,0.0000893496,5.758028e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003375239,"about_ca_system_score_gemma":0.0002258589,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002276434,"about_ca_topic_score_gemma":0.0001002911,"domain_scores_codex":[0.998459,0.0001367791,0.0003994451,0.0005019105,0.0001934408,0.0003094169],"domain_scores_gemma":[0.9993376,0.00003354769,0.0002025704,0.0001397223,0.0001143354,0.0001722527],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001838079,0.000148464,0.004976808,0.0001506625,0.0001765228,0.000002471123,0.003651723,0.000004045724,0.6766009,0.0001148196,0.0006032489,0.3117323],"study_design_scores_gemma":[0.005252216,0.0001224216,0.05351997,0.00003873854,0.00001737965,0.000002803859,0.0001115486,0.0001106402,0.9261796,0.0002997362,0.01398932,0.0003556073],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8418351,0.1571344,0.0002442147,0.0001349234,0.00005867828,0.0004997841,0.0000333194,0.00001092367,0.00004862607],"genre_scores_gemma":[0.908268,0.09024146,0.000913927,0.0002801187,0.00004794947,0.0001010539,0.00003388512,0.00002492107,0.00008873385],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3113767,"threshold_uncertainty_score":0.9999805,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01372272287753717,"score_gpt":0.2355998324564319,"score_spread":0.2218771095788947,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}