{"id":"W3026086046","doi":"10.2147/dddt.s242514","title":"<p>A Triple Combination of Metformin, Acetylsalicylic Acid, and Oseltamivir Phosphate Impacts Tumour Spheroid Viability and Upends Chemoresistance in Triple-Negative Breast Cancer</p>","year":2020,"lang":"en","type":"article","venue":"Drug Design Development and Therapy","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; University of British Columbia; Queen's University","funders":"Natural Sciences and Engineering Research Council of Canada; Queen's University; Russian Foundation for Basic Research","keywords":"Triple-negative breast cancer; Cancer research; Viability assay; Breast cancer; Apoptosis; Cancer; Medicine; Biology; Chemistry; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00010256,0.0002118401,0.0002939751,0.0001698544,0.0001426761,0.000276851,0.000162828,0.0002274707,0.001361703],"category_scores_gemma":[0.00006722372,0.0001004067,0.0002109126,0.0001265753,0.000142692,0.0002050562,0.0001190986,0.0003632235,0.0002773844],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002457057,"about_ca_system_score_gemma":0.0002399183,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001075604,"about_ca_topic_score_gemma":0.001395591,"domain_scores_codex":[0.999922,0.000009077546,0.000007671591,0.00001476686,0.00002893103,0.0000175644],"domain_scores_gemma":[0.999964,0.000006169944,0.000007859955,0.000003280459,0.000006597294,0.00001209487],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003659975,0.00008840743,0.0004037991,0.0001191139,0.00001377166,0.00009553709,0.00002135161,0.0001692171,0.9911283,0.0001305003,0.0006873808,0.006776449],"study_design_scores_gemma":[0.00005112349,0.001148288,0.003335773,0.00001274556,0.00004030683,0.0003048169,0.0000416738,0.001722412,0.9883103,0.00004419162,0.004980066,0.000008268227],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909314,0.003205844,0.001365468,0.0002725475,0.0001048557,0.00004929133,0.0004959482,0.0001596698,0.003414864],"genre_scores_gemma":[0.9930702,0.001532283,0.002081449,0.00008819416,0.00001307789,0.00005230367,0.00048446,0.00001690914,0.002661177],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001361703,"threshold_uncertainty_score":0.004555345,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01372272287753717,"score_gpt":0.2355998324564319,"score_spread":0.2218771095788947,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}