{"id":"W3026095852","doi":"10.1038/s41598-020-65640-7","title":"Extracellular vesicles from genetically unstable, oncogene-driven cancer cells trigger micronuclei formation in endothelial cells","year":2020,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Research Institute in Oncology and Hematology; CancerCare Manitoba; McGill University Health Centre","funders":"Canadian Institutes of Health Research; McGill University Health Centre; McGill University","keywords":"HRAS; Biology; Cancer cell; Genome instability; Cell biology; Cancer research; Cancer; Micronucleus test; Genetics; DNA damage; Chemistry; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001890947,0.0001665741,0.0001850152,0.0001215963,0.0001234418,0.0002768169,0.00009412597,0.0002642149,0.0005211495],"category_scores_gemma":[0.0001282018,0.00009138649,0.0001863984,0.00008914551,0.0001230524,0.0001835161,0.0002462383,0.0003476024,0.0001811272],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001857083,"about_ca_system_score_gemma":0.0001159636,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003724754,"about_ca_topic_score_gemma":0.0004795988,"domain_scores_codex":[0.9998155,0.00004268247,0.00002183215,0.00003485659,0.00004816254,0.00003700802],"domain_scores_gemma":[0.9999131,0.0000274477,0.00002081506,0.0000143729,0.00001141486,0.00001277307],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005122798,0.000007946541,0.0001279903,0.00002669938,0.000007735206,0.0000688373,0.00002146467,0.00007111949,0.9986746,0.0002066625,0.00002589232,0.000709787],"study_design_scores_gemma":[0.000005170838,0.00008807991,0.001240264,0.000003744916,0.000005900694,0.0002402602,0.00002068676,0.0003568319,0.9966279,0.00006689695,0.001342279,0.000001921548],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895034,0.002086192,0.006243651,0.00007912712,0.00003983177,0.00003091024,0.000316635,0.00005093837,0.001649347],"genre_scores_gemma":[0.9962732,0.0005375409,0.001628956,0.00003678958,0.000004787266,0.00001832038,0.0003127863,0.00001258537,0.001175187],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005211495,"threshold_uncertainty_score":0.001743436,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01261424442132643,"score_gpt":0.2345930302765039,"score_spread":0.2219787858551775,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}