{"id":"W3026116304","doi":"10.1038/s41598-020-65038-5","title":"CDH6 and HAGH protein levels in plasma associate with Alzheimer’s disease in APOE ε4 carriers","year":2020,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Stichting Dioraphte; Innovative Medicines Initiative; Erasmus Medisch Centrum; Alzheimer Nederland; ZonMw; European Commission; European Federation of Pharmaceutical Industries and Associations; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Weston Brain Institute","keywords":"Apolipoprotein E; Alzheimer's disease; Cerebrospinal fluid; Genome-wide association study; Internal medicine; Transthyretin; Blood proteins; Endocrinology; Medicine; Molecular biology; Immunology; Biology; Disease; Single-nucleotide polymorphism; Genetics; Gene; Genotype","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003850321,0.0005243024,0.0004365553,0.0008761566,0.0004398857,0.0004881593,0.0002268069,0.0006342925,0.002400743],"category_scores_gemma":[0.001482586,0.0003143097,0.0002660656,0.0007901295,0.0002895341,0.0002538515,0.0002831063,0.000409108,0.0002624114],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001637602,"about_ca_system_score_gemma":0.00006567372,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001687341,"about_ca_topic_score_gemma":0.0009760886,"domain_scores_codex":[0.9998077,0.00004785339,0.00002356954,0.00005525781,0.00004107896,0.00002457974],"domain_scores_gemma":[0.9993051,0.0001809411,0.000303993,0.00005209716,0.0000600512,0.00009779591],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001828878,0.00008171961,0.9851544,0.00002604175,0.0001640677,0.0006458646,0.0001947995,0.00006053607,0.009291979,0.00003909856,0.0001668882,0.002345651],"study_design_scores_gemma":[0.00003687144,0.0002303659,0.9971541,0.000006474897,0.00008747049,0.001001702,0.000130533,0.0002153097,0.0007658204,0.00009742536,0.0002674698,0.000006444741],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993662,0.0002603378,0.00007051045,0.00002466895,0.000005469067,0.000002473697,0.0001121652,0.000004940711,0.0001531894],"genre_scores_gemma":[0.9993361,0.00006273073,0.0001514698,0.00001960206,0.000009171667,0.000003214815,0.0001228743,0.000002159541,0.0002926871],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002400743,"threshold_uncertainty_score":0.008031309,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02269221109376744,"score_gpt":0.249706150253985,"score_spread":0.2270139391602175,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}