{"id":"W3026217555","doi":"10.7150/thno.44962","title":"Dysregulated expression of monoacylglycerol lipase is a marker for anti-diabetic drug metformin-targeted therapy to correct impaired neurogenesis and spatial memory in Alzheimer's disease","year":2020,"lang":"en","type":"article","venue":"Theranostics","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Ottawa Hospital; Heart and Stroke Foundation; Université Laval; University of Ottawa","funders":"National Institute of Diabetes and Digestive and Kidney Diseases","keywords":"Monoacylglycerol lipase; Neurogenesis; Metformin; Medicine; Drug; Disease; Diabetes mellitus; Pharmacology; Drug-naïve; Neuroscience; Internal medicine; Endocrinology; Psychology; Endocannabinoid system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002296932,0.0002591751,0.0002489886,0.0004303093,0.0001350717,0.0005283447,0.0001413515,0.0002942395,0.0008536804],"category_scores_gemma":[0.0002229846,0.00008524068,0.0002451141,0.0001889981,0.000276278,0.0002460339,0.0002154468,0.0006654467,0.0002555165],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003909736,"about_ca_system_score_gemma":0.0002670871,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004894392,"about_ca_topic_score_gemma":0.0007263965,"domain_scores_codex":[0.9999005,0.00001685824,0.00001088808,0.00002375918,0.00002470053,0.00002339585],"domain_scores_gemma":[0.9999127,0.00001162044,0.00003027916,0.00001001145,0.0000181846,0.00001715445],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001002697,0.00006574787,0.007021482,0.00006647874,0.00002683058,0.0002580649,0.00002872175,0.00006819038,0.98048,0.0003128506,0.0001491499,0.01051973],"study_design_scores_gemma":[0.0000635459,0.000759159,0.08925129,0.00003649559,0.0001485598,0.001220488,0.000198083,0.001852031,0.9012646,0.0009069461,0.004275871,0.0000228613],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9878173,0.005335792,0.004308505,0.000476691,0.00009601866,0.0000365885,0.0004624766,0.00009539563,0.001371244],"genre_scores_gemma":[0.9955714,0.001253174,0.001715617,0.0001304606,0.00001239676,0.00002900539,0.000249611,0.000009811178,0.001028608],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008536804,"threshold_uncertainty_score":0.002855897,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01546891802664498,"score_gpt":0.2418493088563893,"score_spread":0.2263803908297443,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}