{"id":"W3026314653","doi":"10.3389/fcimb.2020.00228","title":"Utilizing Organoid and Air-Liquid Interface Models as a Screening Method in the Development of New Host Defense Peptides","year":2020,"lang":"en","type":"review","venue":"Frontiers in Cellular and Infection Microbiology","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University; University of British Columbia","funders":"Canadian Institutes of Health Research; Killam Trusts; Simon Fraser University; Michael Smith Health Research BC","keywords":"Computational biology; Antimicrobial peptides; Drug development; Biology; Innate immune system; Organoid; Drug discovery; Induced pluripotent stem cell; Drug; Immune system; Peptide; Cell biology; Bioinformatics; Biochemistry; Pharmacology; Embryonic stem cell; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009315752,0.0007901374,0.0006300227,0.0007101379,0.0003465292,0.001123521,0.0005776153,0.0009347109,0.001233979],"category_scores_gemma":[0.0004571775,0.0003301357,0.0008157195,0.0004492152,0.0005938284,0.0009558006,0.000998441,0.00154333,0.001201237],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005134002,"about_ca_system_score_gemma":0.0004868465,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006839582,"about_ca_topic_score_gemma":0.001143882,"domain_scores_codex":[0.9993163,0.0001687536,0.00004394293,0.0001811866,0.0002284486,0.00006127205],"domain_scores_gemma":[0.9995481,0.0001739635,0.00008462448,0.00005839732,0.00007846499,0.00005637324],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001019965,0.00006755588,0.000277726,0.0003443814,0.00002062152,0.0002493105,0.00008199003,0.001630283,0.9883768,0.001187544,0.0003637855,0.007297903],"study_design_scores_gemma":[0.00002222051,0.0005786153,0.0006338488,0.00006358082,0.00004610933,0.0003520469,0.0001069858,0.008359838,0.967676,0.0006821256,0.02142962,0.0000489038],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"review","genre_scores_codex":[0.3798644,0.03164377,0.5607334,0.001153082,0.0007622704,0.001358082,0.004408808,0.002747071,0.01732923],"genre_scores_gemma":[0.7334068,0.02044573,0.2321481,0.0006582186,0.00008113196,0.001581068,0.003653814,0.0002857313,0.007739311],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.001233979,"threshold_uncertainty_score":0.004926682,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03583367441302395,"score_gpt":0.2860075914190091,"score_spread":0.2501739170059852,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}