{"id":"W3026608846","doi":"10.1002/mds.28056","title":"CSF NFL in a Longitudinally Assessed PD Cohort: Age Effects and Cognitive Trajectories","year":2020,"lang":"en","type":"article","venue":"Movement Disorders","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Novartis Pharma; Michael J. Fox Foundation for Parkinson's Research","keywords":"Neurofilament; Medicine; Internal medicine; Cognition; Cerebrospinal fluid; Cohort; Cognitive decline; Psychology; Disease; Dementia; Psychiatry; Immunohistochemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006108694,0.0003972224,0.0003597126,0.0006708758,0.0009761755,0.0008817523,0.0003295644,0.0005198469,0.0009673676],"category_scores_gemma":[0.001137902,0.0003083969,0.0004492375,0.0005393711,0.0003177641,0.0005867545,0.0005766131,0.0006877083,0.0003404173],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004553678,"about_ca_system_score_gemma":0.000351177,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01484969,"about_ca_topic_score_gemma":0.01329362,"domain_scores_codex":[0.9997373,0.00003788875,0.00002178297,0.0001074427,0.00004382101,0.00005168693],"domain_scores_gemma":[0.9991611,0.00006730156,0.0003267642,0.00007201175,0.0001781396,0.0001947056],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003325211,0.00004615311,0.9978005,0.000003624394,0.00004596467,0.0001831057,0.0001333158,0.00001517157,0.0004956803,0.000008823272,0.00007137502,0.000863738],"study_design_scores_gemma":[0.000007488227,0.0001710502,0.9990287,0.00000326195,0.00002379025,0.0003893656,0.0001146097,0.00006685415,0.00005807464,0.00001202303,0.0001220819,0.000002796908],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995926,0.00006072747,0.0000290001,0.0000112642,0.000002085383,0.000003592732,0.0001950795,0.000001918733,0.0001038249],"genre_scores_gemma":[0.9991857,0.00004935795,0.00005072819,0.00001447107,0.000004722094,0.000006388469,0.0004655311,0.000002319415,0.0002207086],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01484969,"threshold_uncertainty_score":0.02952653,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0121630339839955,"score_gpt":0.2492991420139538,"score_spread":0.2371361080299583,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}