{"id":"W3026609787","doi":"10.1002/art.41315","title":"Lorecivivint, a Novel Intraarticular CDC‐like Kinase 2 and Dual‐Specificity Tyrosine Phosphorylation‐Regulated Kinase 1A Inhibitor and Wnt Pathway Modulator for the Treatment of Knee Osteoarthritis: A Phase II Randomized Trial","year":2020,"lang":"en","type":"article","venue":"Arthritis & Rheumatology","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":142,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; WOMAC; Osteoarthritis; Placebo; Randomized controlled trial; Population; Internal medicine; Knee pain; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003408895,0.0005485337,0.002018453,0.0001317921,0.0004054748,0.00005340768,0.0000689398,0.0002807814,0.0001124227],"category_scores_gemma":[0.0003682119,0.0004156938,0.0003999875,0.0002410923,0.0007543658,0.0001580805,0.00008185419,0.0001497306,0.000006623031],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005696378,"about_ca_system_score_gemma":0.000144153,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001032619,"about_ca_topic_score_gemma":0.0001420335,"domain_scores_codex":[0.9969905,0.0001691433,0.001180062,0.0007981609,0.0002979595,0.0005641577],"domain_scores_gemma":[0.9978279,0.000722594,0.0003714091,0.0004064849,0.0002328572,0.0004387275],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5956848,0.004054864,0.0001214638,0.0001392581,0.0006172071,0.000239265,0.004690116,0.000005424757,0.05545888,0.008117484,0.0001410871,0.3307301],"study_design_scores_gemma":[0.8896005,0.05008507,0.00002607437,0.0003802751,0.0004745402,0.0005660011,0.0003655067,0.001556398,0.05273449,0.0004466535,0.003386644,0.0003779043],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9587716,0.02989561,0.0008602875,0.002043642,0.0006111313,0.007372034,0.0003035053,0.0001242649,0.00001786061],"genre_scores_gemma":[0.9925733,0.003914391,0.001402122,0.000209853,0.0001650533,0.001368092,0.0002181939,0.00007139713,0.00007755679],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3303522,"threshold_uncertainty_score":0.9998295,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01493393572801894,"score_gpt":0.2412738630149971,"score_spread":0.2263399272869782,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}