{"id":"W3026609787","doi":"10.1002/art.41315","title":"Lorecivivint, a Novel Intraarticular CDC‐like Kinase 2 and Dual‐Specificity Tyrosine Phosphorylation‐Regulated Kinase 1A Inhibitor and Wnt Pathway Modulator for the Treatment of Knee Osteoarthritis: A Phase II Randomized Trial","year":2020,"lang":"en","type":"article","venue":"Arthritis & Rheumatology","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":142,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; WOMAC; Osteoarthritis; Placebo; Randomized controlled trial; Population; Internal medicine; Knee pain; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002191558,0.001431994,0.001949756,0.0003370997,0.0003754248,0.0008186022,0.0008135395,0.001576691,0.004662681],"category_scores_gemma":[0.001257335,0.0005263627,0.001130477,0.0003786258,0.0007902386,0.0006248814,0.0002861215,0.001754116,0.0006832526],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005236209,"about_ca_system_score_gemma":0.001381866,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006602527,"about_ca_topic_score_gemma":0.001636654,"domain_scores_codex":[0.9993203,0.0004063784,0.00004167455,0.0001009325,0.00005066201,0.00008011321],"domain_scores_gemma":[0.9994386,0.0001366495,0.0001705519,0.00003622299,0.00004776015,0.0001702946],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.966466,0.0077009,0.0005605076,0.000848321,0.0006797567,0.00003944975,0.00004272223,0.000314193,0.005496515,0.0001199519,0.0008647409,0.01686688],"study_design_scores_gemma":[0.9401309,0.05725614,0.0008783452,0.00003316126,0.0002689365,0.0000321575,0.00001210074,0.000330903,0.0004418746,0.00005844067,0.0005496845,0.000007194287],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9719295,0.008617573,0.001847277,0.000872076,0.0004463168,0.01144141,0.001876686,0.0002056448,0.002763555],"genre_scores_gemma":[0.9653513,0.005673746,0.004037939,0.001583214,0.0005444991,0.01599534,0.001973926,0.00003202714,0.004807853],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004662681,"threshold_uncertainty_score":0.01559824,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01493393572801894,"score_gpt":0.2412738630149971,"score_spread":0.2263399272869782,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}