{"id":"W3026644645","doi":"10.1038/s41467-020-16379-2","title":"TNFAIP8 controls murine intestinal stem cell homeostasis and regeneration by regulating microbiome-induced Akt signaling","year":2020,"lang":"en","type":"article","venue":"Nature Communications","topic":"Immune cells in cancer","field":"Immunology and Microbiology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; U.S. Department of Health and Human Services; National Cancer Institute; Perelman School of Medicine, University of Pennsylvania; University of Pennsylvania; Children's Hospital of Philadelphia","keywords":"Regeneration (biology); Homeostasis; Stem cell; Cell biology; Microbiome; Protein kinase B; Biology; Signal transduction; Cell; Bioinformatics; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001126516,0.0002573625,0.0001523562,0.00034961,0.0001399177,0.0003089702,0.0001591893,0.0002627211,0.001479789],"category_scores_gemma":[0.00007761444,0.0001403853,0.0001870235,0.0001403197,0.0002247247,0.0001701472,0.0002215596,0.0005392706,0.0005432765],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002728956,"about_ca_system_score_gemma":0.0001122353,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001826713,"about_ca_topic_score_gemma":0.0002654727,"domain_scores_codex":[0.9998467,0.00002556849,0.0000162235,0.0000326952,0.0000351233,0.00004366973],"domain_scores_gemma":[0.9998492,0.00000958593,0.00006141479,0.00001604152,0.00001168064,0.0000521318],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001565436,0.00002729391,0.0002890466,0.00001669967,0.000001855347,0.00002660617,0.000006467496,0.00003936783,0.9985318,0.00006946267,0.0000282039,0.0008065811],"study_design_scores_gemma":[0.00002667487,0.0004375917,0.009741177,0.000009933688,0.00001297557,0.0002100604,0.00005158827,0.001261272,0.9862248,0.0000767926,0.001941967,0.000005186193],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995233,0.0009864012,0.00168905,0.00008088609,0.00002083922,0.0000185285,0.0004868214,0.0001345912,0.001349767],"genre_scores_gemma":[0.9960086,0.0003542314,0.001094481,0.00002759613,0.000004583627,0.00002226515,0.0002825534,0.00001472931,0.002190829],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001479789,"threshold_uncertainty_score":0.004950345,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02204531911331286,"score_gpt":0.2613774889833635,"score_spread":0.2393321698700506,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}