{"id":"W3026647982","doi":"10.1158/1557-3265.ovcasymp18-gmm-048","title":"Abstract GMM-048: CTDNA RESPONSE TO THE PARP INHIBITOR RUCAPARIB PREDICTS PROGRESSION-FREE SURVIVAL AND BEST OVERALL RESPONSE ON THE ARIEL2 TRIAL","year":2019,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"PARP inhibitor; Loss of heterozygosity; Oncology; Medicine; Internal medicine; Ovarian cancer; Progression-free survival; Cancer; Biology; Allele; Chemotherapy; Genetics; Poly ADP ribose polymerase; DNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00143008,0.000383612,0.000862029,0.000168739,0.0001371281,0.0006267862,0.0004241833,0.0004563709,0.004392856],"category_scores_gemma":[0.001369264,0.0001377723,0.0005509452,0.0002329148,0.0002161171,0.0003831188,0.0002430307,0.001154415,0.0005044347],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003900418,"about_ca_system_score_gemma":0.0003539589,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003738813,"about_ca_topic_score_gemma":0.001154021,"domain_scores_codex":[0.9994583,0.0002887682,0.00002739427,0.000124578,0.00005273167,0.00004821697],"domain_scores_gemma":[0.9992558,0.0002559134,0.0001709897,0.00007431724,0.00005504202,0.0001879539],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.6889842,0.002247197,0.1491243,0.001109852,0.003377001,0.0001694499,0.000117729,0.003900482,0.01898596,0.0003138524,0.01233299,0.1193371],"study_design_scores_gemma":[0.1613454,0.1178252,0.6732638,0.0002307179,0.005698232,0.0008147777,0.0001613179,0.01270943,0.009498109,0.001040492,0.0173033,0.0001091698],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9887636,0.002827078,0.000274078,0.0006353286,0.00007788771,0.0001905106,0.003717844,0.0001198034,0.003393827],"genre_scores_gemma":[0.9936776,0.000270651,0.0003577161,0.0002893464,0.0001025981,0.0001670852,0.003663391,0.00001586045,0.001455844],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004392856,"threshold_uncertainty_score":0.01469558,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2549700596045747,"score_gpt":0.530908562304738,"score_spread":0.2759385027001633,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}