{"id":"W3026740871","doi":"10.1016/j.annonc.2020.03.139","title":"3O Mutation analysis of circulating tumour DNA from baseline and study discontinuation samples in SANDPIPER, a phase III study of taselisib or placebo with fulvestrant in oestrogen receptor-positive, human epidermal growth factor receptor 2-negative, PIK3CA-mutant advanced breast cancer","year":2020,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Hospital","funders":"","keywords":"Fulvestrant; PTEN; Medicine; Internal medicine; Cancer research; Cancer; Oncology; PI3K/AKT/mTOR pathway; Estrogen receptor; Breast cancer; Biology; Genetics; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000682008,0.0002653583,0.0004440327,0.0005404452,0.0002942805,0.0005883281,0.0003144406,0.0005486034,0.004119175],"category_scores_gemma":[0.001227017,0.0002268465,0.0003827248,0.0003116368,0.0002204422,0.0002278292,0.0001342453,0.0004303351,0.0003828207],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003575509,"about_ca_system_score_gemma":0.0004466771,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001375033,"about_ca_topic_score_gemma":0.002988444,"domain_scores_codex":[0.9995614,0.000101031,0.00003004904,0.0001422127,0.00008440227,0.00008092864],"domain_scores_gemma":[0.9995639,0.0001335308,0.0001182856,0.00004172639,0.00005088357,0.00009171112],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.1386149,0.002322693,0.2763269,0.0003872817,0.001437073,0.000554243,0.0005768188,0.001432326,0.4106217,0.0003435238,0.003926693,0.1634558],"study_design_scores_gemma":[0.01322763,0.04586356,0.807029,0.00007261982,0.001417966,0.002621196,0.000222343,0.004714164,0.1139492,0.000449946,0.01036711,0.00006529681],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947944,0.0006899356,0.0008271288,0.00007753172,0.0000303905,0.0001537447,0.002363853,0.0001051411,0.0009578405],"genre_scores_gemma":[0.9934819,0.0001478182,0.001423748,0.0001647958,0.00001495614,0.0001373194,0.002790885,0.00002847589,0.001810003],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004119175,"threshold_uncertainty_score":0.01378006,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04333580127687771,"score_gpt":0.3517512217719729,"score_spread":0.3084154204950952,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}