{"id":"W3026744271","doi":"10.3791/61256","title":"Hepatic Progenitor Specification from Pluripotent Stem Cells using a Defined Differentiation System","year":2020,"lang":"en","type":"article","venue":"Journal of Visualized Experiments","topic":"Liver physiology and pathology","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Stemcell Technologies","funders":"Medical Research Council; UK Regenerative Medicine Platform","keywords":"Progenitor cell; Induced pluripotent stem cell; Embryonic stem cell; Directed differentiation; Economic shortage; Stem cell; Progenitor; Biology; Cellular differentiation; Transplantation; Immunology; Medicine; Cell biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007644828,0.0003652338,0.0002232488,0.0004413444,0.0002604992,0.0005462598,0.0003330698,0.0003308841,0.0009085719],"category_scores_gemma":[0.0003979666,0.0002105692,0.0002418161,0.0003337395,0.0003258363,0.0002701722,0.000574821,0.0007313396,0.000608411],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002506542,"about_ca_system_score_gemma":0.0006423016,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003248825,"about_ca_topic_score_gemma":0.0009402928,"domain_scores_codex":[0.9995614,0.000074208,0.0001106824,0.00006792314,0.0001491787,0.0000365884],"domain_scores_gemma":[0.9997602,0.00005917092,0.00005533745,0.00004031229,0.00005665925,0.00002836221],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003065159,0.00001691912,0.0002186011,0.00008990515,0.000003638663,0.00008289096,0.0000428388,0.0002231373,0.9946803,0.000609802,0.00007904074,0.003922266],"study_design_scores_gemma":[0.00001835644,0.0002408981,0.001338091,0.00003849528,0.00002686735,0.0002567254,0.00004386934,0.001466556,0.9842967,0.0001524239,0.01210706,0.00001400473],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.6372683,0.004831253,0.3418565,0.000318309,0.0002491155,0.001875046,0.00243086,0.0006647583,0.01050587],"genre_scores_gemma":[0.7824239,0.005017187,0.1986358,0.0002361262,0.00003999508,0.001362902,0.00481989,0.0001641715,0.007299939],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.0009085719,"threshold_uncertainty_score":0.004043043,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07823561830545678,"score_gpt":0.3798362884460234,"score_spread":0.3016006701405666,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}