{"id":"W3026934713","doi":"10.1084/jem.20191094","title":"Distinct fibroblast functional states drive clinical outcomes in ovarian cancer and are regulated by TCF21","year":2020,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":102,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; University of Toronto","funders":"Canadian Institutes of Health Research; University of Toronto; Ontario Institute for Cancer Research; Princess Margaret Cancer Foundation; Amgen","keywords":"Fibroblast activation protein, alpha; Cancer research; Cancer-Associated Fibroblasts; Transcription factor; Regulator; Cancer; Biology; Tumor microenvironment; Medicine; Cell biology; Internal medicine; Tumor cells; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003498662,0.0001347578,0.0005430538,0.00006786673,0.00005100181,0.000005777369,0.00006293452,0.00004708326,0.001027708],"category_scores_gemma":[0.0001948039,0.00007156476,0.00009360764,0.0001774933,0.0002963551,0.00006787865,0.00003412805,0.0003303238,0.000003646773],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005727405,"about_ca_system_score_gemma":0.00003946556,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008640811,"about_ca_topic_score_gemma":0.00001344991,"domain_scores_codex":[0.998594,0.0001100402,0.0006876999,0.0001191577,0.000362029,0.0001270848],"domain_scores_gemma":[0.9990024,0.0001990129,0.0003534176,0.00008262182,0.00008196243,0.0002806169],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.004733716,0.000805473,0.3972127,0.00005452091,0.0008632562,0.0003003256,0.004855029,0.00003087333,0.4699778,0.00003055943,0.1204409,0.0006948905],"study_design_scores_gemma":[0.0247739,0.004541392,0.893931,0.003554743,0.0005700354,0.0004596752,0.02310225,0.001520228,0.04469992,0.00008216705,0.002450625,0.0003140606],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.927926,0.001422105,0.00009430846,0.07028072,0.00005762625,0.00009503905,0.00001408774,0.00000720754,0.0001028728],"genre_scores_gemma":[0.9931821,0.000175512,0.0000333923,0.005959226,0.0004088495,0.000002007969,0.00001735791,0.00001122214,0.0002103888],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4967183,"threshold_uncertainty_score":0.9998855,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04050462647251605,"score_gpt":0.3498081617957801,"score_spread":0.309303535323264,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}