{"id":"W3027043096","doi":"10.1183/13993003.00117-2020","title":"Suboptimal treatment response to anti-IL-5 monoclonal antibodies in severe eosinophilic asthmatics with airway autoimmune phenomena","year":2020,"lang":"en","type":"article","venue":"European Respiratory Journal","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":121,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Institut universitaire de cardiologie et de pneumologie de Québec; McMaster University; Université Laval; Université de Montréal; McGill University Health Centre; St. Joseph’s Healthcare Hamilton","funders":"Institute of Circulatory and Respiratory Health; Canadian Institutes of Health Research; McMaster University","keywords":"Medicine; Mepolizumab; Sputum; Immunology; Asthma; Prednisone; Eosinophil; Internal medicine; Gastroenterology; Pathology; Tuberculosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007513313,0.0004914539,0.0007154573,0.0003901315,0.000300485,0.0001342438,0.0002773971,0.00006024501,0.000255429],"category_scores_gemma":[0.0002170995,0.0003491344,0.000215655,0.0005386593,0.0001622657,0.0002115673,0.0001135417,0.0005543972,0.0004217905],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002845129,"about_ca_system_score_gemma":0.000706746,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001572682,"about_ca_topic_score_gemma":0.000001795187,"domain_scores_codex":[0.9964368,0.0009779303,0.0008300284,0.0005092705,0.0006170257,0.0006289814],"domain_scores_gemma":[0.9979544,0.00008920535,0.0002688361,0.0004148874,0.0001787936,0.001093848],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.06060799,0.003716056,0.4484497,0.0004439923,0.00102441,0.07598696,0.01699305,0.02075947,0.2332074,0.00005167033,0.00894074,0.1298186],"study_design_scores_gemma":[0.007869419,0.01249826,0.7656428,0.0004823747,0.0001307885,0.000935585,0.001075172,0.0001759018,0.001352353,0.000001490922,0.2092239,0.0006120055],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924889,0.001514337,0.0001626516,0.002410878,0.00009797914,0.0005034589,0.00003997501,0.0001107008,0.002671178],"genre_scores_gemma":[0.9909894,0.00005800603,0.001846582,0.00566934,0.0009000577,0.000007259594,0.00000579168,0.0001350895,0.0003884254],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3171931,"threshold_uncertainty_score":0.999896,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02696391970027819,"score_gpt":0.2629310261893054,"score_spread":0.2359671064890272,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}