{"id":"W3027049653","doi":"10.1210/endocr/bqaa078","title":"Of Mice and Men, Redux: Modern Challenges in β Cell Gene Targeting","year":2020,"lang":"en","type":"letter","venue":"Endocrinology","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Sunnybrook Health Science Centre; Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research","keywords":"Redux; Internal medicine; Endocrinology; Medicine; Gene; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01013951,0.001543297,0.00220567,0.000712571,0.002641143,0.004649804,0.001640967,0.0340786,0.004194503],"category_scores_gemma":[0.02233836,0.0006909961,0.001533137,0.0005112723,0.006567394,0.007830286,0.002264541,0.05019328,0.003044307],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002998065,"about_ca_system_score_gemma":0.002468177,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002184042,"about_ca_topic_score_gemma":0.00377233,"domain_scores_codex":[0.9954154,0.001651258,0.0004605069,0.0006120548,0.001436586,0.000424201],"domain_scores_gemma":[0.9886203,0.008155386,0.000474936,0.0003693425,0.0009997219,0.001380329],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001751786,0.00007864647,0.0003552877,0.000137917,0.00003690265,0.001255485,0.0001740094,0.0001298257,0.0005934374,0.01183755,0.9531976,0.03202815],"study_design_scores_gemma":[0.0001751815,0.0001537112,0.0003808012,0.0002251972,0.00002886895,0.001683563,0.0003014589,0.000345424,0.0002833203,0.02700958,0.9693457,0.00006720008],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0002701719,0.01047623,0.0005939721,0.958437,0.02901086,0.000006536018,0.00002019743,0.00004834311,0.001136642],"genre_scores_gemma":[0.004134104,0.01013914,0.001025417,0.8747612,0.1028309,0.00004511523,0.00002379202,0.00005289557,0.006987465],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.0340786,"threshold_uncertainty_score":0.0536235,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03874946719841683,"score_gpt":0.2506801087332637,"score_spread":0.2119306415348469,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}