{"id":"W3027058750","doi":"10.1002/etc.4783","title":"Evaluation of the Aryl Hydrocarbon Receptor Response in LMH 3D Spheroids","year":2020,"lang":"en","type":"article","venue":"Environmental Toxicology and Chemistry","topic":"Toxic Organic Pollutants Impact","field":"Environmental Science","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Genomics; University of Ottawa; Environment and Climate Change Canada","funders":"Environment and Climate Change Canada","keywords":"Aryl hydrocarbon receptor; Spheroid; Cell culture; Cytochrome P450; In vitro; Gene expression; Biology; Molecular biology; Cell biology; Chemistry; Receptor; Gene; Biochemistry; Enzyme; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002276959,0.0002894974,0.0003338225,0.0002678618,0.0002369818,0.0003199601,0.00013079,0.0003316319,0.001231401],"category_scores_gemma":[0.0001522622,0.0001551413,0.0003718552,0.0002679177,0.000199411,0.0001692123,0.0002047539,0.0004862832,0.0006281345],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003394631,"about_ca_system_score_gemma":0.0001980397,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001800218,"about_ca_topic_score_gemma":0.00350568,"domain_scores_codex":[0.9997491,0.00003937374,0.00002689946,0.00006217797,0.00009253814,0.00002990635],"domain_scores_gemma":[0.999757,0.00007456464,0.00003979736,0.00003827198,0.00005473395,0.00003562411],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004283555,0.00001945362,0.0005228451,0.00002838973,0.000004788045,0.0000557886,0.00002965163,0.00009593825,0.9985072,0.00003192272,0.00004838739,0.0006128494],"study_design_scores_gemma":[0.000008644362,0.0003111718,0.01604088,0.000007158921,0.00002569112,0.0002152257,0.0001245485,0.001666348,0.978094,0.00003167331,0.003464122,0.00001049001],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9746922,0.001657056,0.01725073,0.000165691,0.0001198192,0.0002060292,0.002499824,0.0002416791,0.00316712],"genre_scores_gemma":[0.9661705,0.001293119,0.02072867,0.000179261,0.00002723218,0.0003518656,0.003922467,0.0000630079,0.007263991],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001800218,"threshold_uncertainty_score":0.004119456,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01125308210210413,"score_gpt":0.2209596527435607,"score_spread":0.2097065706414566,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}