{"id":"W3027074285","doi":"10.1016/j.celrep.2020.107634","title":"β-Glucan Induces Protective Trained Immunity against Mycobacterium tuberculosis Infection: A Key Role for IL-1","year":2020,"lang":"en","type":"article","venue":"Cell Reports","topic":"Immune responses and vaccinations","field":"Immunology and Microbiology","cited_by":328,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"European Research Council; Canadian Institutes of Health Research; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Medical Research Council; Fonds de Recherche du Québec - Santé; National Health and Medical Research Council; Bill and Melinda Gates Foundation","keywords":"Mycobacterium tuberculosis; Immunity; Microbiology; Tuberculosis; Glucan; Immunology; Key (lock); Biology; Immune system; Medicine; Biochemistry; Pathology; Ecology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000213129,0.0005740539,0.0001343563,0.0002434567,0.00009437321,0.0003096614,0.0001500769,0.0003888651,0.003006995],"category_scores_gemma":[0.0001765952,0.00009039875,0.0002087475,0.0001213241,0.0002678807,0.000212942,0.0002402715,0.0009500314,0.0007945544],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001292752,"about_ca_system_score_gemma":0.000164369,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001031985,"about_ca_topic_score_gemma":0.0001751691,"domain_scores_codex":[0.999886,0.00003014829,0.000009733976,0.00002104154,0.00001941772,0.00003358887],"domain_scores_gemma":[0.9998884,0.00001910574,0.00002816546,0.00001488527,0.00001397833,0.00003549239],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003926469,0.0002675132,0.0008669173,0.0001919513,0.000011401,0.000130644,0.00002376802,0.00005244839,0.9808301,0.000272918,0.000280018,0.01667959],"study_design_scores_gemma":[0.000191093,0.003803735,0.02372241,0.00009115079,0.00006910224,0.0009218247,0.00007997476,0.0004378393,0.9526531,0.000752685,0.01726339,0.00001369481],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9669813,0.01601117,0.005408835,0.001102264,0.000699194,0.0001421277,0.0005368317,0.0003020746,0.008816239],"genre_scores_gemma":[0.9871224,0.004737321,0.002309797,0.0004828299,0.0002180879,0.00007399452,0.0005569154,0.00002047967,0.004478365],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003006995,"threshold_uncertainty_score":0.01005942,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01498283323553853,"score_gpt":0.2375826216192793,"score_spread":0.2225997883837408,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}