{"id":"W3027156164","doi":"10.3389/fmicb.2020.00935","title":"Transcriptome Analysis Uncovers a Link Between Copper Metabolism, and Both Fungal Fitness and Antifungal Sensitivity in the Opportunistic Yeast Candida albicans","year":2020,"lang":"en","type":"article","venue":"Frontiers in Microbiology","topic":"Trace Elements in Health","field":"Nursing","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research","keywords":"Candida albicans; Biology; Transcriptome; Virulence; Yeast; Microbiology; Mutant; Copper; Transcription factor; Gene; Corpus albicans; Antifungal drug; Fungus; Gene expression; Genetics; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001055846,0.0002681577,0.0003565147,0.0003967677,0.000308061,0.0005637454,0.0001283294,0.0002039745,0.0006073881],"category_scores_gemma":[0.0001569702,0.0001330506,0.000403804,0.0005843666,0.0001453055,0.0001903737,0.0003192465,0.0004723863,0.000153985],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002559105,"about_ca_system_score_gemma":0.0003790476,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001860228,"about_ca_topic_score_gemma":0.002527944,"domain_scores_codex":[0.9998682,0.000007382945,0.000007866362,0.00005422518,0.00003189257,0.00003036042],"domain_scores_gemma":[0.9999092,0.00002129778,0.00002042071,0.000009049181,0.00002329775,0.00001687839],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001806588,0.00001745358,0.004816635,0.00008434773,0.00001688427,0.0001018022,0.00005594138,0.0002170985,0.9898081,0.00007850894,0.0001815965,0.004440979],"study_design_scores_gemma":[0.00002391548,0.0004344959,0.6426091,0.00006301773,0.0002264321,0.0008139736,0.0008420887,0.01204579,0.3340161,0.0007913428,0.008076488,0.00005720177],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907674,0.001260934,0.002538841,0.0001165236,0.0000212422,0.00001431645,0.004312806,0.00009495884,0.0008729685],"genre_scores_gemma":[0.9871092,0.001271838,0.004023894,0.0001377374,0.00001959802,0.00003855273,0.005740578,0.00004187087,0.001616744],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001860228,"threshold_uncertainty_score":0.003698766,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02097226272485073,"score_gpt":0.2632482512238229,"score_spread":0.2422759884989722,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}