{"id":"W3027190879","doi":"10.3389/fimmu.2020.00965","title":"The Network of Colonic Host Defense Peptides as an Innate Immune Defense Against Enteropathogenic Bacteria","year":2020,"lang":"en","type":"review","venue":"Frontiers in Immunology","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Alberta Agriculture and Forestry","keywords":"Immune system; Biology; Antimicrobial peptides; Innate immune system; Microbiology; Cathelicidin; Defensin; Immunology; Colitis; Shigella; Inflammation; Antimicrobial; Salmonella; Bacteria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001432181,0.0002943228,0.000258779,0.0002647919,0.0001041412,0.0004646387,0.0001412211,0.0002825349,0.0007483189],"category_scores_gemma":[0.00009904339,0.00006410798,0.000184207,0.000246185,0.0001614305,0.0003270388,0.0002803494,0.0003789268,0.0002296726],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001858834,"about_ca_system_score_gemma":0.0002350896,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001744696,"about_ca_topic_score_gemma":0.0002634769,"domain_scores_codex":[0.9999155,0.00003049761,0.000006459408,0.00001573423,0.00001702741,0.00001474332],"domain_scores_gemma":[0.9999493,0.000008395041,0.00001564443,0.00000249661,0.00001092954,0.000013232],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005606983,0.00005802048,0.001766796,0.004210711,0.0001133702,0.001352408,0.0001440448,0.0007327936,0.7497177,0.004870344,0.001807394,0.2346657],"study_design_scores_gemma":[0.0001433163,0.00365839,0.05694879,0.001565649,0.0007133925,0.010671,0.000538988,0.002413799,0.308173,0.007767954,0.6073136,0.00009215924],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.2057672,0.7657557,0.01116109,0.00195435,0.0006794594,0.00007930813,0.0002573581,0.0001396426,0.01420593],"genre_scores_gemma":[0.5200849,0.4571022,0.01067718,0.0009240253,0.0006320064,0.0001125669,0.0002967368,0.00002188304,0.01014845],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.0007483189,"threshold_uncertainty_score":0.002503335,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01221299445257005,"score_gpt":0.2410315690498716,"score_spread":0.2288185745973015,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}