{"id":"W3027359205","doi":"10.1093/toxsci/kfaa072","title":"Characterizations of Human UDP-Glucuronosyltransferase Enzymes in the Conjugation of p-Cresol","year":2020,"lang":"en","type":"article","venue":"Toxicological Sciences","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"University of Alberta","keywords":"Glucuronidation; Glucuronide; Chemistry; Microsome; Enzyme; Biochemistry; Kidney; Metabolism; Pharmacology; Toxicity; Internal medicine; Endocrinology; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001036319,0.0001155234,0.00025019,0.00006154089,0.0001845416,0.00001260058,0.0005947213,0.0001210084,0.001242085],"category_scores_gemma":[0.0001715428,0.00007429925,0.00007197186,0.0006435441,0.0008704243,0.00008375971,0.00005135922,0.0002760481,0.00000983603],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005798013,"about_ca_system_score_gemma":0.00005653163,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001009683,"about_ca_topic_score_gemma":0.000006545492,"domain_scores_codex":[0.9982437,0.0006133002,0.0004432977,0.0002281818,0.0002278035,0.0002436808],"domain_scores_gemma":[0.9991841,0.0004387131,0.0001507169,0.00007584238,0.00004632067,0.0001043422],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006293777,0.0004443834,0.01609824,0.00002398991,0.00001432569,0.000005772554,0.002373245,0.0008281562,0.926367,0.04995959,0.0001812003,0.003641138],"study_design_scores_gemma":[0.00140531,0.001061875,0.09946487,0.000009733239,0.00008274642,0.000003285843,0.0006962382,0.004916707,0.8753129,0.002037477,0.0147842,0.0002247062],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988939,0.0005029267,0.0001161333,0.004565455,0.0001290575,0.0003582623,0.00005736262,0.00001679031,0.005315019],"genre_scores_gemma":[0.9958032,0.0001796796,0.00008467564,0.003796085,0.00008898616,0.00002572108,0.000008463099,0.000003199964,0.000009930862],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08336663,"threshold_uncertainty_score":0.9996709,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3516262852390853,"score_gpt":0.4897178063162866,"score_spread":0.1380915210772014,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}