{"id":"W3027479247","doi":"10.1101/2020.05.18.099887","title":"Novel insights into the structure and transport mechanisms of TAPT1","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genetic and Kidney Cyst Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Alberta Innovates; Shahjalal University of Science and Technology","keywords":"Cilium; In silico; Ciliopathies; Transmembrane protein; Transmembrane domain; Biophysics; Computational biology; Protein structure; Mutant; Biology; Chemistry; Gene; Cell biology; Crystallography; Genetics; Biochemistry; Phenotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001152425,0.0003802094,0.0002655195,0.0002220932,0.0002910513,0.0003744742,0.000311117,0.0005088278,0.001313069],"category_scores_gemma":[0.0001371494,0.0001284551,0.0004863868,0.0001801307,0.0002132919,0.0006672277,0.0002531784,0.0005929996,0.0002787524],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003431477,"about_ca_system_score_gemma":0.0002327172,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006480215,"about_ca_topic_score_gemma":0.0003128242,"domain_scores_codex":[0.9999521,0.000006144843,0.000002627414,0.00001342503,0.0000159918,0.000009780497],"domain_scores_gemma":[0.9999602,0.000008529737,0.00000902212,0.000003603863,0.000008982662,0.000009684964],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000199817,0.00005473842,0.0025954,0.0004031053,0.00002938715,0.001343415,0.0001241672,0.006812963,0.9704733,0.007678535,0.0005094677,0.009775778],"study_design_scores_gemma":[0.00007311972,0.0003365153,0.009240638,0.00007744584,0.00014917,0.003358793,0.0004551398,0.364093,0.5834742,0.01825642,0.02041321,0.00007236847],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9433111,0.008703433,0.04245293,0.0008806542,0.00008562453,0.00002539177,0.0004737973,0.0002483504,0.00381873],"genre_scores_gemma":[0.9862663,0.002671229,0.009742743,0.00009139285,0.00002295606,0.00001283227,0.0004208979,0.00001805633,0.0007536345],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001313069,"threshold_uncertainty_score":0.004392624,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007477911137163929,"score_gpt":0.1967531076161975,"score_spread":0.1892751964790336,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}