{"id":"W3027569065","doi":"10.3390/ijms21103654","title":"Differential ESR1 Promoter Methylation in the Peripheral Blood—Findings from the Women 40+ Healthy Aging Study","year":2020,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Douglas Mental Health University Institute","funders":"Universität Zürich; Eidgenössische Technische Hochschule Zürich","keywords":"DNA methylation; Methylation; Estrogen receptor alpha; Promoter; Epigenetics; Estrogen receptor; Biology; CpG site; Estrogen; DNA; Endocrinology; Gene; Internal medicine; Andrology; Medicine; Genetics; Gene expression; Cancer; Breast cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002603951,0.0001672756,0.0002246876,0.0002995761,0.0003097201,0.0002673859,0.0001221797,0.0002385904,0.0009016022],"category_scores_gemma":[0.0004496751,0.0001533615,0.0001710423,0.000401476,0.000112404,0.0001145369,0.0001931559,0.0002114984,0.0001481034],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008532795,"about_ca_system_score_gemma":0.00009853122,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003574163,"about_ca_topic_score_gemma":0.004236221,"domain_scores_codex":[0.9998879,0.00002668729,0.000009775132,0.00004170359,0.00001572104,0.00001817811],"domain_scores_gemma":[0.9998465,0.00001902284,0.0000499645,0.00001187362,0.00002342198,0.00004914837],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000592534,0.00004615214,0.9926875,0.00001896896,0.000103085,0.0001416229,0.0002906952,0.00001656199,0.003191541,0.00001480057,0.0001469054,0.002749827],"study_design_scores_gemma":[0.00001206154,0.0001213884,0.9991159,0.000002392075,0.00004912042,0.0001654045,0.0001139112,0.00002663972,0.0001404191,0.00001850999,0.0002327122,0.000001579359],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992261,0.0002337863,0.0000622993,0.00001870316,0.000004015548,0.000004088648,0.0002636567,0.000001743883,0.0001855842],"genre_scores_gemma":[0.9994274,0.00008816963,0.0000493369,0.00002800407,0.000005949733,0.000005788565,0.0001814744,0.000001113423,0.0002127935],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003574163,"threshold_uncertainty_score":0.007106721,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02169583793532413,"score_gpt":0.3068572051704042,"score_spread":0.2851613672350801,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}