{"id":"W3027616822","doi":"10.1177/0269881120922950","title":"One (effect) size does not fit at all: Interpreting clinical significance and effect sizes in depression treatment trials","year":2020,"lang":"en","type":"article","venue":"Journal of Psychopharmacology","topic":"Treatment of Major Depression","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Novo Nordisk Fonden; National Institute for Health and Care Research; Novo Nordisk; H. Lundbeck A/S; Lundbeckfonden; King's College London; National Alliance for Research on Schizophrenia and Depression; Michael Smith Health Research BC; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; Canadian Institutes of Health Research; British Medical Association; Wellcome Trust","keywords":"Rating scale; Hamilton Rating Scale for Depression; Psychopathology; Clinical significance; Depression (economics); Psychology; Major depressive disorder; Clinical psychology; Clinical trial; Antidepressant; Psychiatry; Internal medicine; Medicine; Mood; Anxiety; Developmental psychology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002462511,0.0003066237,0.001910348,0.0001234662,0.00004767615,0.00001692435,0.0001364096,0.0002467517,0.0004483861],"category_scores_gemma":[0.00317522,0.0001760396,0.0004160893,0.0001077771,0.000108143,0.0001065262,0.00008233168,0.0005470716,0.00001480022],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002365891,"about_ca_system_score_gemma":0.00006600437,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009289423,"about_ca_topic_score_gemma":0.000005696371,"domain_scores_codex":[0.9951634,0.00217113,0.001590557,0.0004366736,0.0003256686,0.0003126123],"domain_scores_gemma":[0.98812,0.01012448,0.001052405,0.0001504665,0.00005819892,0.000494523],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.07061099,0.0007312435,0.3204674,0.0001312036,0.0007468312,0.0008054184,0.0003894224,0.00001279433,0.5423582,2.237411e-7,0.002341823,0.06140446],"study_design_scores_gemma":[0.1323421,0.03820721,0.410407,0.001014934,0.00359678,0.000380246,0.00004944708,0.0003889894,0.4036675,0.00002831265,0.009534267,0.000383294],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9864562,0.002239777,0.00001298209,0.008795291,0.001246243,0.001109619,0.000009001381,0.00002940497,0.0001014465],"genre_scores_gemma":[0.9929394,0.002545772,0.0007394193,0.002629257,0.0009746167,0.00004499064,0.000001706942,0.00003414591,0.00009073889],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1386907,"threshold_uncertainty_score":0.7178687,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08610502266336843,"score_gpt":0.4534324041463764,"score_spread":0.367327381483008,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}