{"id":"W3027623583","doi":"10.3390/life10050073","title":"Higher Responsiveness to Rosuvastatin in Polygenic versus Monogenic Hypercholesterolemia: A Propensity Score Analysis","year":2020,"lang":"en","type":"article","venue":"Life","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"British Heart Foundation; Heart and Stroke Foundation of British Columbia and Yukon","keywords":"Rosuvastatin; Familial hypercholesterolemia; Medicine; Internal medicine; Polygenic risk score; Apolipoprotein B; Propensity score matching; Gastroenterology; Cholesterol; Endocrinology; Genetics; Biology; Gene; Genotype","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001827643,0.0003787397,0.0005346913,0.0009990081,0.000434953,0.0007947084,0.000326367,0.0006176449,0.002299403],"category_scores_gemma":[0.002863693,0.0002192114,0.001526671,0.000906339,0.0003931232,0.0003203499,0.0006044218,0.0006669476,0.0002268637],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002117622,"about_ca_system_score_gemma":0.0002658985,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001420046,"about_ca_topic_score_gemma":0.001047772,"domain_scores_codex":[0.9987513,0.0005013277,0.0001266244,0.0003247017,0.000152542,0.0001435327],"domain_scores_gemma":[0.9977484,0.0007265834,0.0007294032,0.0003370784,0.0001104243,0.0003482208],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001875332,0.00009122361,0.9929959,0.00001129589,0.0009421438,0.0001735668,0.00007245981,0.000379522,0.00108822,0.0001170209,0.00009800811,0.002155372],"study_design_scores_gemma":[0.00006027865,0.0004691371,0.9922664,0.000005840438,0.0004251895,0.0004936095,0.0001067751,0.00554272,0.0001326681,0.000235688,0.0002488265,0.00001272431],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989625,0.0001044665,0.0006763138,0.00002993433,0.000006121073,0.000008989623,0.00006739492,0.000003822973,0.0001405521],"genre_scores_gemma":[0.9997314,0.00001400125,0.00008682816,0.00001049759,0.000004998364,0.000003955669,0.00007368364,0.000002079511,0.00007256149],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002299403,"threshold_uncertainty_score":0.009665608,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08746032301922682,"score_gpt":0.2989107516019167,"score_spread":0.2114504285826899,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}