{"id":"W3027623583","doi":"10.3390/life10050073","title":"Higher Responsiveness to Rosuvastatin in Polygenic versus Monogenic Hypercholesterolemia: A Propensity Score Analysis","year":2020,"lang":"en","type":"article","venue":"Life","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"British Heart Foundation; Heart and Stroke Foundation of British Columbia and Yukon","keywords":"Rosuvastatin; Familial hypercholesterolemia; Medicine; Internal medicine; Polygenic risk score; Apolipoprotein B; Propensity score matching; Gastroenterology; Cholesterol; Endocrinology; Genetics; Biology; Gene; Genotype","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003890856,0.0001649949,0.0006735956,0.000197883,0.00004478318,0.00002229439,0.0001197931,0.0001013069,0.0001072885],"category_scores_gemma":[0.0002928825,0.0001431977,0.0003397166,0.001632464,0.0000220549,0.0000564132,0.0001011772,0.0002791091,0.0001322901],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001183579,"about_ca_system_score_gemma":0.0003292124,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000479947,"about_ca_topic_score_gemma":0.0002009915,"domain_scores_codex":[0.998247,0.0001925467,0.0003212998,0.0004672569,0.0004420967,0.000329823],"domain_scores_gemma":[0.9986629,0.00003527641,0.00004700946,0.0005366296,0.00008754927,0.0006306279],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.03739788,0.0004520772,0.8970343,0.0006971796,0.005800597,0.001396915,0.00483231,0.002302524,0.01940557,0.0001427053,0.001697148,0.02884073],"study_design_scores_gemma":[0.004192614,0.0005607665,0.9884776,0.00004389335,0.0008135194,0.000005279846,0.000136967,0.0001179397,0.0009362091,0.000002425536,0.00452204,0.0001907372],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907256,0.0005091024,0.0002841415,0.007362224,0.0001062804,0.0007311752,0.00001160556,0.00005535583,0.0002145373],"genre_scores_gemma":[0.9916254,0.00002236924,0.0003955647,0.007403702,0.0003045694,0.00005864525,0.00002048902,0.00002647415,0.0001428139],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09144325,"threshold_uncertainty_score":0.5839434,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08746032301922682,"score_gpt":0.2989107516019167,"score_spread":0.2114504285826899,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}