{"id":"W3027715520","doi":"10.1093/jncics/pkaa042","title":"Postmenopausal Hormone Therapy and Colorectal Cancer Risk by Molecularly Defined Subtypes and Tumor Location","year":2020,"lang":"en","type":"article","venue":"JNCI Cancer Spectrum","topic":"Menopause: Health Impacts and Treatments","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Ontario Institute for Cancer Research; University of Toronto; Mount Sinai Hospital","funders":"Cancer Council Victoria; Centers for Disease Control and Prevention; Harvard T.H. Chan School of Public Health; Brigham and Women's Hospital; Centre International de Recherche sur le Cancer; World Health Organization; National Cancer Institute; National Institutes of Health; Vetenskapsrådet; U.S. Department of Health and Human Services","keywords":"Medicine; Microsatellite instability; Colorectal cancer; KRAS; Internal medicine; Oncology; Odds ratio; Cancer; Adenoma; Colorectal adenoma; Allele; Biology; Microsatellite","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002008982,0.0003199903,0.000908943,0.00135953,0.000180061,0.0007632028,0.0003950252,0.0003200278,0.000978338],"category_scores_gemma":[0.003473277,0.0002079289,0.00169484,0.00222199,0.000235757,0.0002228371,0.0004306484,0.0002453873,0.00009053541],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001942335,"about_ca_system_score_gemma":0.0003204232,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004461089,"about_ca_topic_score_gemma":0.004077971,"domain_scores_codex":[0.9986081,0.0005590409,0.0002522817,0.0003403665,0.0001722129,0.00006809953],"domain_scores_gemma":[0.9954969,0.001566607,0.001976519,0.0005147204,0.0002930348,0.0001522689],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006990112,0.000008063893,0.9890654,0.0002501775,0.004656712,0.00006235493,0.00003247193,0.0002342945,0.0010568,0.00004354683,0.00008661437,0.00380457],"study_design_scores_gemma":[0.00005416322,0.0001788165,0.9931797,0.00008127087,0.004117838,0.0003944139,0.00005366546,0.0005669827,0.0003875771,0.0001653167,0.0008117885,0.000008458424],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9655037,0.02941454,0.001139465,0.0001194188,0.00003395732,0.00003296679,0.003068463,0.00002455362,0.0006629227],"genre_scores_gemma":[0.9976312,0.00135217,0.0002905813,0.00003178652,0.00002854828,0.00001574566,0.0005603343,0.000004105019,0.00008553421],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004461089,"threshold_uncertainty_score":0.01062471,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01870782641469291,"score_gpt":0.2859654769012827,"score_spread":0.2672576504865897,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}