{"id":"W3027715520","doi":"10.1093/jncics/pkaa042","title":"Postmenopausal Hormone Therapy and Colorectal Cancer Risk by Molecularly Defined Subtypes and Tumor Location","year":2020,"lang":"en","type":"article","venue":"JNCI Cancer Spectrum","topic":"Menopause: Health Impacts and Treatments","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Ontario Institute for Cancer Research; University of Toronto; Mount Sinai Hospital","funders":"Cancer Council Victoria; Centers for Disease Control and Prevention; Harvard T.H. Chan School of Public Health; Brigham and Women's Hospital; Centre International de Recherche sur le Cancer; World Health Organization; National Cancer Institute; National Institutes of Health; Vetenskapsrådet; U.S. Department of Health and Human Services","keywords":"Medicine; Microsatellite instability; Colorectal cancer; KRAS; Internal medicine; Oncology; Odds ratio; Cancer; Adenoma; Colorectal adenoma; Allele; Biology; Microsatellite","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007168013,0.0002267318,0.000339793,0.00004231176,0.0001336504,0.00004091931,0.00004149946,0.00006315447,0.0001185751],"category_scores_gemma":[0.00003580486,0.0001772859,0.000008172638,0.0002153286,0.00006711017,0.00009525262,0.00002345258,0.0001885388,0.000007676027],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001718731,"about_ca_system_score_gemma":0.0002967472,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007451799,"about_ca_topic_score_gemma":0.0002950082,"domain_scores_codex":[0.9987669,0.00004023103,0.0002123804,0.0003926967,0.0002299255,0.0003578434],"domain_scores_gemma":[0.9991853,0.00002778348,0.0001380666,0.0001220221,0.00005025524,0.0004765399],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01653314,0.0006020118,0.4776209,0.0005462868,0.001292798,0.0003376866,0.003553297,0.00001768503,0.4409678,0.0002924015,0.01644433,0.04179167],"study_design_scores_gemma":[0.01598597,0.01866717,0.9218911,0.0001051817,0.0005130838,0.00008260425,0.00006681518,0.001850125,0.03469422,0.0002285017,0.005434812,0.0004804333],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9222156,0.06348769,0.00005271162,0.01303212,0.00009450533,0.0007130191,0.0001534247,0.00006057421,0.000190307],"genre_scores_gemma":[0.976333,0.01877142,0.0001557826,0.004266017,0.0002115388,0.0001203697,0.0000299705,0.00004060701,0.00007135524],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4442702,"threshold_uncertainty_score":0.9991577,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01870782641469291,"score_gpt":0.2859654769012827,"score_spread":0.2672576504865897,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}