{"id":"W3027849952","doi":"10.1101/gad.336487.120","title":"A central role for canonical PRC1 in shaping the 3D nuclear landscape","year":2020,"lang":"en","type":"article","venue":"Genes & Development","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":149,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Biotechnology and Biological Sciences Research Council; Medical Research Council; Directorate for Biological Sciences; Royal Society; Darwin Trust of Edinburgh; Wellcome Trust","keywords":"Biology; Chromatin; CTCF; Gene silencing; Transcription factor; Regulation of gene expression; Genetics; Cell biology; Embryonic stem cell; Gene; Transcriptional regulation; Computational biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001074052,0.0002058703,0.0001381562,0.0001551165,0.0004133973,0.0008097818,0.0003140608,0.0002611657,0.001705791],"category_scores_gemma":[0.0001291479,0.0002114633,0.0001718379,0.0001041213,0.0005731425,0.0004657538,0.0004241997,0.0003908046,0.0005894495],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005277729,"about_ca_system_score_gemma":0.0004100755,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007212376,"about_ca_topic_score_gemma":0.001715052,"domain_scores_codex":[0.9999104,0.000009034706,0.00000376359,0.00003249904,0.00002960649,0.00001475332],"domain_scores_gemma":[0.9999067,0.00001043292,0.0000209396,0.0000166959,0.00001333057,0.00003186629],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003759403,0.000005328301,0.00120328,0.00003959606,0.000006000994,0.00009148578,0.00003222239,0.0004389747,0.9901242,0.002840513,0.00009609495,0.005084601],"study_design_scores_gemma":[0.00001776878,0.0001067825,0.0346644,0.00001820996,0.00001767353,0.001195076,0.0001307404,0.008268174,0.9393593,0.002287147,0.0139101,0.00002451746],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9069077,0.004408172,0.07500871,0.0006382568,0.00005551994,0.00003934007,0.0004505854,0.0004761904,0.01201558],"genre_scores_gemma":[0.9880442,0.000733123,0.008409655,0.00005883092,0.000008109369,0.00001497609,0.0001573417,0.0000281205,0.002545558],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001705791,"threshold_uncertainty_score":0.005706429,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0121802884597486,"score_gpt":0.2117228985139781,"score_spread":0.1995426100542295,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}