{"id":"W3027849952","doi":"10.1101/gad.336487.120","title":"A central role for canonical PRC1 in shaping the 3D nuclear landscape","year":2020,"lang":"en","type":"article","venue":"Genes & Development","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":149,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Biotechnology and Biological Sciences Research Council; Medical Research Council; Directorate for Biological Sciences; Royal Society; Darwin Trust of Edinburgh; Wellcome Trust","keywords":"Biology; Chromatin; CTCF; Gene silencing; Transcription factor; Regulation of gene expression; Genetics; Cell biology; Embryonic stem cell; Gene; Transcriptional regulation; Computational biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008097417,0.00009881045,0.00009012345,0.000008902515,0.00007804332,0.00002483158,0.0001924679,0.00006534945,0.00001524013],"category_scores_gemma":[0.00001644457,0.00007963386,0.00003928027,0.0000409414,0.00001514403,0.000001112556,0.0001352668,0.00004532757,0.000005569922],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001936164,"about_ca_system_score_gemma":0.0001852419,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005295175,"about_ca_topic_score_gemma":0.0001139064,"domain_scores_codex":[0.9992731,0.00001363625,0.0001748151,0.0002186973,0.0000636724,0.0002560391],"domain_scores_gemma":[0.9997625,0.00000551013,0.00003678276,0.0001087931,0.00002019249,0.00006625978],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004938631,0.0002049915,0.04052038,0.000184826,0.0003222082,0.0000126582,0.009378756,0.008772122,0.7899315,0.0008927612,0.006028106,0.1432579],"study_design_scores_gemma":[0.001234462,0.0001541547,0.03253077,0.0000170514,0.0000155012,0.00001008202,0.0009120584,0.02230662,0.0239896,0.00005178822,0.9183493,0.0004285645],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968419,0.0008252891,0.0007932339,0.0009165854,0.00006563713,0.0002464582,0.000008137459,0.000007475604,0.000295265],"genre_scores_gemma":[0.989133,0.0001349952,0.009212445,0.001196172,0.0001443726,0.00003875214,0.0000807776,0.00002074061,0.00003876751],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9123213,"threshold_uncertainty_score":0.3247375,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0121802884597486,"score_gpt":0.2117228985139781,"score_spread":0.1995426100542295,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}